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Ambenonium

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Ambenonium

Ambenonium review





Ambenonium, also known by the trade name of Mytelase and the chemical name of ambenonium dichloride, is a cholinesterase inhibitor used to treat myasthenia gravis. Myasthenia gravis (muscle disease) happens when the body creates antibodies against acetylcholine receptors, which hampers signal transmission across the myoneural junction.

This drug is recommended for people who need to treat muscle weakness due to muscle disease (myasthenia gravis). It is classified as a reversible drug that works against myasthenia gravis by aggressive reversible hampering of acetylcholinesterase (the enzyme needed to make the hydrolysis of acetylcholine possible).

By reversibly binding and deactivating acetylcholinesterase, ambenonium effectively boosts the acetylcholine levels in your body and, in turn, aids the delivery of impulses across the myoneural junction, which effectively treats the condition.

Dosage is based upon your response to the treatment and present medical condition. Regardless, the typical daily recommended dose for ambenonium is 40 milligrams once daily, but some patients may require up to 50 to 75 milligrams every day depending on the severity of their sickness. Take ambenonium orally as prescribed by your doctor. The incorrect use of this drug can lead to severe side effects.

You must not exceed your dosage without prior medical recommendation. Furthermore, you should learn all the directions for proper use of this medication, including how to change your drug dosage or how to use ambenonium as needed. Finally, consult with your pharmacist or doctor for further information.

The most common side effect of ambenonium is nausea. If this symptom worsens or persists, consult your doctor immediately. You should also report to your healthcare specialist if you have any of these symptoms as well: eye changes ranging from pinpoint pupils to increased tears, urinary urgency, increased sweating, increased saliva production, stomach pain, diarrhea, and headache.

Seek medical help once you get any of these rare but grave side effects: dizziness, muscle weakness, muscle cramps or spasms, vision changes, swallowing difficulties, breathing difficulties, and unusually slow pulse. Get emergency medical attention once you get any of these very unlikely but serious side effects: mental or mood changes, seizures, loss of coordination, and chest pain. If you notice side effects not listed above, consult your pharmacist or doctor immediately.

Inform your healthcare specialist of your medical history, particularly of any allergies, urinary problems like ureter or bladder obstruction; thyroid problems like the hyperthyroid condition; heart problems like bradycardia, arrythmia, and coronary occlusion; stomach or intestinal problems like ulcers, stomach or intestinal obstruction, and megacolon; nerve problems like vagotonia; seizures; and lung problems like asthma.

You should also report to your doctor all the nonprescription and prescription drugs you're using and have used, particularly drugs like magnesium supplements, muscle relaxants like baclofen, cholinergic drugs like bethanecol, heart rhythm drugs like quinidine, local or general anesthetics like lidocaine, aminoglycoside antibiotics like neomycin, atropine, and mecamylamine. You must not begin or halt any medication without prior pharmacist or doctor approval.

You should not take this drug if you have allergies to any of the ingredients found in ambenonium, if you have blockage in your stomach/intestine/bladder, or if you are taking atropine, belladonna, quinine, cholinergic agents like guanidine, and ganglionic blocking agents like mecamylamine. Consult your healthcare provider or pharmacist if any of these instances apply to you.

It is currently unknown whether or not this drug passes into breast milk, so you must seek medical advice before proceeding to nurse your baby while under ambenonium therapy. Finally, expecting mothers should only take ambenonium when necessary. Consult your doctor and discuss with him the pros and cons of using ambenonium while pregnant.

Ambenonium has the following structural formula:

Chemical structure of ambenonium


• Molecular formula of ambenonium is C28H42Cl2N4O2
• Chemical IUPAC Name is (2-chlorophenyl)methyl-[2-[2-[(2-chlorophenyl)methyl-diethyl-ammonio] ethylcarbamoylformyl]aminoethyl]-diethyl-ammonium
• Molecular weight is 537.564 g/mol

Brand name(s): Ambenonum, Mytelase

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