Amiprazidine review

Your body naturally balances the chemicals it produces; however, sometimes it needs help from outside sources. Amiprazidine is used to counteract hypertension and congestive heart failure. Since these diseases come from an overload of sodium in the body, Amiprazidine (more commonly known to doctors as a Potassium-sparing diuretic) is used to keep potassium in the body but release sodium. More specifically, it keeps sodium and water from being absorbed in the kidneys. Unlike other diuretics Amiprazidine keeps the potassium from seeping out which helps normalize the functions of the heart and the kidneys.

Sometimes, due to the amount of potassium the body handles, patients using this medication experience hyperkalemia, which is a high blood potassium level. Using ACE inhibitors and spironolactone usually trigger this condition. Hyperkalemia is easily managed by adjusting the dosage of Amiprazidine. To help regulate the body fluids, this medication is usually taken with thiazide and loop diuretics. Doctors often prescribe Amiprazidine with another medication to avoid the patient developing hyperkalemia.

Using medications that increase the levels of potassium in the body is very delicate. Patients need to consult with their doctor and disclose their full medical history as well as any and all prescription and non-prescription medications they are taking. This would include any medication for high blood pressure, potassium supplements, or diabetes, lithium (especially dangerous to be taking while on Amiprazidine), medications like captopril, digoxin, and lisinopril (all dangerous when taken with Amiprazidine), spironolactone (can increase your potassium to a dangerous level when taken with Amiprazidine).

A patient’s medical history needs to include information regarding a history of liver, kidney or heart disease. Amiprazidine increases the body’s potassium and the organs recovering from the above diseases might be susceptible to the change.

Having a renal disease is particularly hard when taking Amiprazidine since this makes the body more susceptible to hyperkalemia. Consult your doctor to determine if this medication is right for you.

Amiprazidine has some common side effects that include headache, fatigue, upset stomach, gas, nausea, muscle cramps, and frequent urination. Another common side effect is drowsiness. Patients taking this medication should not drive or operate heavy machinery.

Some less common side effects include impotence, vertigo, heartburn, back and chest pain. Patients that experience skin rashes, yellow eyes or skin, difficulty breathing or an irregular heartbeat should contact their doctor immediately. If you experience any of these side effects, consult your doctor immediately.

Amiprazidine is usually distributed under the name Midamor in 5mg and 10 mg tablets. These tablets are usually yellow and diamond shaped. Doses start at 5mg daily and then are slowly increased if the patient’s doctor sees fit. Higher doses usually put patients at risk for high blood potassium levels. The effects of the medication last the entire day, but usually it is most effective the first 6-8 hours after taking it. Since the aim of Amiprazidine is to regulate sodium levels, patients are encouraged to follow a low-sodium diet and exercise regularly. Also, it is best to stay away from potassium rich foods like bananas, prunes and raisins while taking Amiprazidine.

Amiprazidine has the following structural formula:

Chemical structure of amiprazidine

• Molecular formula of amiprazidine is C6H8ClN7O
• Chemical IUPAC Name is 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide
• Molecular weight is 229.6270 g/mol
Amiprazidine available : 5mg tablets

Generic name: Amiloride

Brand name(s): Amilorida, Amiloridum, Amipramidin, Amipramizid, Amipramizide, Amyloride, Guanamprazin, Guanamprazine, Midamor

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