is an effective, popular medication that battles depression
and is considered a tricyclic antidepressant. It works by inhibiting the serotonin and the noradrenaline
reuptake in a patients body. By doing this, Amitryptiline actually increases the levels of those natural body chemicals so that the levels of depression decrease. It is typically sold under the names Elavil
, Tryptanol, Endep
, Elatrol, Tryptizol, Trepiline, and Laroxyl. Amitryptiline also has sedative effects, so it can be used to calm people with anxiety
or violent depression. Typically used by physicians to treat clinical depression and depression in the elderly; however, in some countries it is used to treat chronic migraines
, chronic pain, carpal tunnel syndrome and insomnia
. A medical study done in 2003 compared Amitryptiline with a control group of anti depressants, and almost 90% of the subjects had a more favorable response with Amitryptiline.
The most common known side effects are dry mouth
, drowsiness, dizziness
, blurred vision, insomnia and weight gain. Because of the drowsiness and dizziness that patients experience while taking this medication, they are discouraged from driving or operating heavy machinery while taking Amitryptiline. Less common side effects include mania, abnormally low blood
, and hepatic toxicity. If you experience any of these symptoms, consult your physician immediately.
Patients with a history of seizures, liver
diseases, blood diseases, hyperthyroidism
should make their physician aware before taking Amitryptiline. Any of these conditions may hinder the medication. Patients with heart
disease should be particularly careful since this medication can cause abnormal rhythms in the heart. Patients with manic depressive disorder may experience hypermaniac attacks if given Amitryptiline. Due to this, physicians may want to adjust the dosage or prescribe a different medication for those patients. The use of Amitryptiline has not been approved for pregnant or breastfeeding women. The medicine is passed through breast
milk so mothers should not nurse their children while they are taking the medication.
Patients should talk with their physician about any and all medication that they are taking before they use Amitryptiline. Medications like cisapride
, monoamine oxidase inhibitors, Marplan, Nardil, Eldepryl, Emsam, Zelapar and Parnate have negative interactions with Amitryptiline. Any medication you are taking may react negatively with Amitryptiline, even simple medications like sleeping pills, antihistamines, diet pills, or herbal vitamins. Make certain that your physician is aware of every medication you are taking, even those that are non-prescription, to be safe.
Amitryptiline should only be taken as prescribed. The tablets are small, white and odorless and come in 10, 25, 50 and 70 mg tablets. The dosage for adults and the elderly is usually 25 to 150 mg daily depending on the severity of the condition being treated. It is very important to take the prescribed dosage as too much of the medication may have negative affects on your mental health
Amitryptiline has the following structural formula:
• Molecular formula of amitryptiline is C20H23N
• Chemical IUPAC Name is 3-(10,11-dihydro-5H-dibenzo-[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine
• Molecular weight is 277.403 g/mol
• Amitryptiline available : 10mg tablets, 25mg tablets, 50mg tablets, 75mg tablets, 100mg tablets, 150mg tablets