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Amphenicol

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Amphenicol

Amphenicol review





Amphenicol is a synthetic antibiotic that was introduced to the medical world in 1949. Since its inception, it has been found useful in treating bacterial infections caused by drug-resistant microorganisms. It has been widely used in many third-world countries because it is inexpensive compared to other antibiotics. In the United States Amphenicol is used rarely due to its suspected role in the patient's increased risk for aplastic anemia. The only popular forms of Amphenicol in the West are ointment and eye drops, used to reduce the symptoms of bacterial conjunctivitis. In other countries, Amphenicol is found useful in treating pneumonia and other bacterial infections that involve the eye and the prostrate gland.

Amphenicol is administered by mouth, through an IV or topically. Oral Amphenicol comes in 250mg capsules and 125mg/5ml liquid suspension while other forms come in a variety of doses. The typical dose is 50mg per kilogram of body weight distributed evenly in four dosing schedules. Severe conditions may require double the typical dose while newborns use only half since they do not metabolize the medication as effectively.

Precautions must be taken before the administration of Amphenicol. Young children, four years and below, using this medication must be closely monitored. Amphenicol may induce abnormal activity of blood cells, causing serious health problems. Since it is metabolized by the liver, any form of liver disorder should be discussed. Patients with liver or kidney illnesss must receive a dose adjustment from their doctors to avoid any more damage. Pregnant and lactating women should not take Amphenicol without the advice of their doctor. Amphenicol may pose harm to the fragile bodies of fetuses and newborns alike.

If you are using other medicaments, inform your doctor about each one of them, including your vitamins. Some medicines react negatively to Amphenicol and must not be taken together.

Amphenicol did not boom in the US because of its harsh side effects. The most severe is aplastic anemia, a condition that is very rare yet can be fatal. It is not yet proven that blood count monitoring can prevent aplastic anemia but it has been widely observed to reduce the possibilities of complications connected with Amphenicol treatment. The higher risk for aplastic anemia is found in patients who are using it orally; the least risky is the eye drops form. Other possible side effects of Amphenicol include bone marrow suppression, childhood leukemia, and Gray Baby Syndrome among others.

To be safe while taking Amphenicol, make sure that you are closely monitored by a doctor. Keeping a close watch on the progress of your symptoms and on the responses of your body to the medication will help your doctor resolve a problem early. Never take the medicine without your doctor's advice and never use another person's or an old prescription for your current condition.

Amphenicol has the following structural formula:

Chemical structure of amphenicol


• Molecular formula of amphenicol is C11H12Cl2N2O5
• Chemical IUPAC Name is 2,2-dichloro-N-[1,3-dihydroxy-1-(4-nitrophenyl)-propan-2-yl]-acetamide
• Molecular weight is 323.129 g/mol
Amphenicol available : 250mg tablets

Generic name: Chloramphenicol

Brand name(s): Alficetyn, Ambofen, Amphicol, Amseclor, Anacetin, Aquamycetin, Austracil, Austracol, Biocetin, Biophenicol, Catilan, Chemicetin, Chemicetina, Chlomin, Chlomycol, Chlora-Tabs, Chloramex, Chloramfenikol, Chloramficin, Chloramfilin, Chloramphenicole, Chloramsaar, Chlorasol, Chloricol, Chlornitromycin, Chlorocaps, Chlorocid, Chlorocide, Chlorocol, Chlorofair, Chloromax, Chloromycetin, Chloromycetny, Chloromyxin, Chloronitrin, Chloroptic, Chlorovules, Cidocetine, Ciplamycetin, Cloramfen, Cloramficin, Cloramicol, Cloramidina, Cloroamfenicolo, Clorocyn, Cloromisan, Clorosintex, Comycetin, Cylphenicol, Desphen, Detreomycin, Detreomycine, Dextromycetin, Doctamicina, Econochlor, Embacetin, Emetren, Enicol, Enteromycetin, Erbaplast, Ertilen, Farmicetina, Farmitcetina, Fenicol, Globenicol, Glorous, Halomycetin, Hortfenicol, Intramycetin, Isicetin, Ismicetina, Isophenicol, Juvamycetin, Kamaver, Kemicetina, Kemicetine, Klorita, Leukamycin, Leukomyan, Leukomycin, Levomicetina, Levomitsetin, Levomycetin, Liquichlor, Loromisan, Loromisin, Mastiphen, Mediamycetine, Medichol, Micloretin, Micochlorine, Micoclorina, Microcetina, Mychel, Mycinol, Normimycin V, Novochlorocap, Novomycetin, Novophenicol, Oftalent, Oleomycetin, Opclor, Opelor, Ophthochlor, Ophthoclor, Ophthocort, Ophtochlor, Optomycin, Otachron, Otophen, Owadziak, Pantovernil, Paraxin, Pedraczak, Pentamycetin, Pflanzol, Quellada, Quemicetina, Rivomycin, Romphenil, Ronphenil, Septicol, Sificetina, Sintomicetina, Sno-Phenicol, Stanomycetin, Synthomycetin, Synthomycetine, Synthomycine, Tevcocin, Tevcosin, Tifomycin, Tifomycine, Tiromycetin, Treomicetina, Tyfomycine, Unimycetin, Veticol, Viceton

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