Amyloride review

Your body naturally balances the chemicals it produces; however, sometimes it needs help from outside sources. Amyloride is used to counteract hypertension and congestive heart failure. Since these diseases come from an overload of sodium in the body, Amyloride (more commonly known to doctors as a Potassium-sparing diuretic) is used to keep potassium in the body but release sodium. More specifically, it keeps sodium and water from being absorbed in the kidneys. Unlike other diuretics Amyloride keeps the potassium from seeping out which helps normalize the functions of the heart and the kidneys.

Sometimes, due to the amount of potassium the body handles, patients using this medication experience hyperkalemia, which is a high blood potassium level. Using ACE inhibitors and spironolactone usually trigger this condition. Hyperkalemia is easily managed by adjusting the dosage of Amyloride. To help regulate the body fluids, this medication is usually taken with thiazide and loop diuretics. Doctors often prescribe Amyloride with another medication to avoid the patient developing hyperkalemia.

Using medications that increase the levels of potassium in the body is very delicate. Patients need to consult with their doctor and disclose their full medical history as well as any and all prescription and non-prescription medications they are taking. This would include any medication for high blood pressure, potassium supplements, or diabetes, lithium (especially dangerous to be taking while on Amyloride), medications like captopril, digoxin, and lisinopril (all dangerous when taken with Amyloride), spironolactone (can increase your potassium to a dangerous level when taken with Amyloride).

A patient’s medical history needs to include information regarding a history of liver, kidney or heart disease. Amyloride increases the body’s potassium and the organs recovering from the above diseases might be susceptible to the change.

Having a renal disease is particularly difficult when taking Amyloride since this makes the body more susceptible to hyperkalemia. Consult your doctor to determine if this medication is right for you.

Amyloride’s common side effects include headache, fatigue, upset stomach, gas, nausea, muscle cramps, and frequent urination. Another common side effect is drowsiness. Patients taking this medication should not drive or operate heavy machinery.

Some less common side effects include impotence, vertigo, heartburn, back and chest pain. Rare but serious side effects include skin rashes, yellow eyes or skin, difficulty breathing or an irregular heartbeat. If you experience any of these side effects, contact your doctor immediately.

Amyloride is distributed under the name Midamor in 5mg and 10 mg tablets. The tablets are usually yellow and diamond shaped. Doses start at 5mg daily and slowly increased as the patient’s doctor sees fit although higher doses usually put patients at risk for high blood potassium levels. The effects of the medication last 24 hours, but is usually most effective in the first 6-8 hours after taking it. Since the aim of Amyloride is to regulate sodium levels, patients are encouraged to change to a low-sodium diet and exercise regularly. It is also best to stay away from potassium rich foods like bananas, prunes and raisins while taking Amyloride.

Amyloride has the following structural formula:

Chemical structure of amyloride

• Molecular formula of amyloride is C6H8ClN7O
• Chemical IUPAC Name is 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide
• Molecular weight is 229.6270 g/mol
Amyloride available : 5mg tablets

Generic name: Amiloride

Brand name(s): Amilorida, Amiloridum, Amipramidin, Amipramizid, Amipramizide, Amiprazidine, Guanamprazin, Guanamprazine, Midamor

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