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Aplonidine

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Aplonidine

Aplonidine review





Aplonidine is a medicament commonly used in glaucoma therapy. This medicament is commonly known as Iopidine, though sometimes distributed as p-aminoclonidine. The medicament is administered to patients when the current treatment is not enough to reduce eye pressure or to reduce eye pressure before and after surgery on the afflicted area.

Patients who want to reduce eye pressure or those who are planning to have laser eye surgery should use Aplonidine. The medicament is commonly used as a means to prevent the rise of pressure that occurs within the eye during this type of surgical procedure.

Prescriptions of Aplonidine includes 0.5% and 1% solution. The 1% solution is commonly used before and after the laser eye surgery; in most cases, one drop is administered before surgery and another drop afterwards. Doctors prescribe Aplonidine 0.5% for home use, while the 1% solution is released by the hospital before the procedure.

For glaucoma, when using Aplonidine 0.5%, medicament is administered one drop in each eye 2 to 3 times a day for adults. For Aplonidine 1%, one drop is administered in the afflicted eye before and after surgery to prevent ocular hypertension. Use of both medicaments on children requires a careful prescription from the doctor.

Common side effects of Aplonidine 0.5% and 1% involve an allergic reaction, which involves eye redness, itching, and tearing. In rare cases, the patient will suffer from blurred vision, disorientation, dizziness, depression, irregular heartbeat, redness of the eyelid, swelling, and breathing troubles.

The above mentioned side effects may require medical intervention, but there may be other reactions that are considered non-fatal; such as dryness of mouth, eye discomfort, and change in smell or taste, discoloration on the afflicted eye, runny nose, sore throat, sudden weaknesses, and sleeping troubles. These minor side effects typically disappear after treatment and require no further prescription from the doctor.

Patients receiving Monoamine oxidase inhibitors should not use Aplonidine. Anti-depressants are said to lower the effectiveness of the medicament, like its hypotensive effect. It is quite possible that use of such medicament might reduce the IOP lowering effect of Aplonidine. Also, an additive hypotensive effect was observed when patients use arpaclonidine with neuroleptic therapy.

Patients who are using both Aplonidine 0.5% and 1% solutions should have their vision monitored periodically. The medicament might cause some patients to suffer from dizziness, somnolence, and being less alert. Those who are suffering from these symptoms must refrain from doing activities that might cause accidents or fatal consequences. Using Aplonidine might also make your eyes more sensitive to sunlight; it is advisable to stay indoors or wear sunglasses to avoid further irritation or discomfort.

Aplonidine has the following structural formula:

Chemical structure of aplonidine


• Molecular formula of aplonidine is C9H10Cl2N4
• Chemical IUPAC Name is 2,6-dichloro-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine
• Molecular weight is 245.108 g/mol

Generic name: Apraclonidine

Brand name(s): Apraclonidina, Apraclonidinum, Iopidine

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