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Apopril

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Apopril

Apopril review





Apopril, an angiotensin-converting enzyme inhibitor, is used in the treatment of high blood pressure (high blood pressure) and cases of congestive heart failure. It keeps a chemical in the blood, angiotensin, from metabolizing into a dangerous substance that allows the body to retain more salt and water, which leads to high blood pressure and eventual heart failure.

Apopril works by relaxing the blood vessels and enabling blood to flow more freely throughout the body. It can be used on its own or with diuretics in the treatment of high blood pressure. For management of congestive heart failure, it is combined with both digitalis and diuretics.

This medication can be used to treat kidney disorders in diabetic patients. It reduces the risk of further cardiac arrest in patients that have previously had a heart attack and can improve the chance of survival after heart failure.

Apopril can be used in the treatment of angina pectoris (a crushing chest pain), rheumatoid arthritis, and Raynaud's phenomenon (a blood vessel disorder).

Patients allergic to Apopril or any of its ingredients, women in the second or third trimester of pregnancy (Apopril can cause fetal death), patients with a history of allergies to ACE inhibitors, and those taking dextran sulfate should not take Apopril.

Before taking Apopril, patients should tell their physician if they have any medical conditions including food, medicine or substance-related allergies, a history of bone marrow depression, high blood potassium levels or low blood sodium levels, a history of kidney disease, or if they are currently undergoing dialysis or have had a previous kidney transplant, a history of heart disease, the autoimmune disease, lupus, a sodium-restricted diet, or if they are breastfeeding.

Apopril can affect the results of some laboratory tests such as urine ketone tests of diabetes patients. Since Apopril may cause adverse reactions when taken with certain medications, patients need to inform their physician of all the medications, including vitamin, mineral and herbal supplements they may be taking.

Some medications that interact with Apopril include dextran sulfate (Allopurinol), which cause allergic reactions; diurectics, which increases the risk of low blood pressure and low blood sodium; NSAIDs (nonsteroidal anti-inflammatory medications), which can lessen the effectiveness of Apopril; Lithium or thiopurines; oral diabetes medications, which may lower blood sugar levels, and Potassium supplements, which may further increase blood potassium levels.

Apopril has been known to cause adverse reactions like coughing, a rash, and a metallic taste in the mouth. Some patients taking Apopril may experience hypotension, a condition where blood pressure becomes abnormally low, and hyperkalemia, which is indicated by excessive potassium in the blood.

Other known side effects include dizziness or lightheadedness, which can be aggravated by alcohol consumption; fainting; fatigue; diarrhea; vomiting; cephalalgias; itching and fever. If the patient experiences severe allergic reactions including hives, itching, breathing difficulties, swelling of the facial tissues, jaundice, irregular heartbeat, fainting and signs of infection like fever and acute pharyngitis, they should discontinue use of Apopril and immediately seek emergency medical attention.

Apopril is distributed by Bristol-Myers Squibb under the brand names Capoten or Inhibace. It is also available under another brand, Capozide. Depending on the patient's condition and the prescription, Apopril usually is taken orally on an empty stomach an hour before meals. For high blood pressure, diabetes-related kidney ailments, and patients recovering from heart failure, the usual dosage is 25 mg., 2 to 3 times a day. Patients recovering from a heart attack are usually give an initial 6.25 mg. dose once, followed by 12.5 mg. 3 times a day. Apopril intake should not exceed 450 mg. daily to prevent an overdose.

Apopril has the following structural formula:

Chemical structure of apopril


• Molecular formula of apopril is C9H15NO3S
• Chemical IUPAC Name is (2S)-1-[(2S)-2-methyl-3-sulfanyl-propanoyl]pyrrolidine-2-carboxylic acid
• Molecular weight is 217.286 g/mol
Apopril available : 12.5mg tablets, 25mg tablets, 50mg tablets, 100mg tablets

Generic name: Captopril

Brand name(s): Acediur, Aceplus, Acepress, Acepril, Alopresin, Capoten, Capozide, Captolane, Captoprilum, Captopryl, Captoril, Cesplon, Dilabar, Garranil, Hipertil, Hypertil, L-Captopril, Lopirin, Lopril, Tenosbon, Tensobon, Tensoprel

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