Aprepitant review

Chemotherapy or cancer drug treatment often results to minor or severe cases of nausea and vomiting. The doctor prescribes aprepitant to reduce or prevent these side effects of the treatment. This medication commonly used to prevent vomiting as a result of chemotherapy, in which the drug contains substances that block the chemical’s substance P and neurokinin 1 that cause vomiting.

Aprepitant is prescribed for cancer patients who are undergoing chemotherapy treatment. In most cases, side effects to these treatments vary depending on the location of cancer cells in their body that requires treatment or your body's reaction to the procedure.

The medication is used for patients who are suffering from severe nausea and vomiting as side effects from their chemotherapy treatment. The same medication may also be used for patients suffering from nausea or vomiting after a surgery or prescribed by doctors for other use or treatment.

The dosage of aprepitant may depend according to the analysis of your doctor or physician in regards to your current condition. The common dose recommended by health care providers is 125mg of aprepitant an hour before your chemotherapy treatment. The recommended dose for the next two days is 80mg taken once a day in the morning after meals.

The patient can also opt for vein infusion in taking in the medication before the chemotherapy session instead of the usual oral intake. Such is the case; recommend dosage is 115mg intravenously.

Health care providers recommend taking 40mg of aprepitant 3 hours before the start of your surgery, and varied doses may be administered according to the prescription of your doctor or physician.

Side effects commonly attributed to the use of aprepitant includes tiredness or weakness, fatigue, diarrhea, nausea or dizziness, gas or constipation, stomach pains, heart burn, hiccups, loss of appetite, fever, headache, itching, and hair loss. Serious side effects may include rashes or hives in the case of severe allergic reaction to the medication.

Aprepitant is known for having adverse interactions with other drugs, specifically over-the-counter medications. It is advisable that you consult your health care provider on the current medication you are taking whether it will cause complications or not. Also, birth control pills and blood clotting drugs may not work well when taken alongside aprepitant.

As with any other medications, it is essential that you seek the advice of a professional in order to determine the effectiveness and safety of using aprepitant. Patients might be advised to undergo physical and medical examination to determine possible allergic reactions to the medication.

Diseases, such as liver or kidney problems, are also known to cause complications when using aprepitant so best tell your doctor about it before undergoing treatment.

Also, the effects of aprepitant might cause dizziness or fatigue. It is advisable to refrain from doing activities, such as driving, swimming, extreme sports, or any other routines that might be considered as a hazard when you are in this condition.

Aprepitant has the following structural formula:

Chemical structure of aprepitant

• Molecular formula of aprepitant is C23H21F7N4O3
• Chemical IUPAC Name is 5-[[2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)- morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one
• Molecular weight is 534.427 g/mol
Aprepitant available : 40mg capsules, 80mg capsules and 125mg capsules

Brand name(s): Emend

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