Arsenic trioxide
Arsenic trioxide

Arsenic trioxide review

Arsenic Trioxide is one of the highly debatable topics in the medical field considering that it is poisonous to the human body. Arsenic trioxide was first used as one of the traditional Chinese medicines called Pi Shuang and is still used today to treat cancer patients and other health conditions.

Today, Arsenic Trioxide, which comes by the name Trisenox, is a medication used to treat patients with leukemia that is unresponsive to other agents. Despite the risks, this drug was given approval for use by the U.S. Food and Drugs Association as a treatment for leukemia.

Arsenic Trioxide or Trisenox is commonly administered to patients suffering from acute promyelocytic leukemia (APL) who have been unresponsive to treatment from "first-line" agents.

Use of arsenic trioxide requires that it be diluted into intravenous solutions. 100 to 250ml of this medication is injected to Dextrose Injection, 0.9% Sodium Chloride Injection, and USP. Keep in mind that a single-dose is stored securely and any leftovers from the ampule should be discarded. Arsenic trioxide is administered 1 to 2 hours intravenously and may be extended to 4 hours if there is acute vasomotor reaction observed on the patient.

For bone marrow therapy, arsenic trioxide is administered at a dose of 0.15 mg per kg weight of the patient daily until bone marrow remission. Total dose should not reach 60.

Using arsenic trioxide should begin 3 t0 6 weeks after completing the induction therapy. It is intravenously administered 0.15 mg per kg weight of the patient daily for 25 to doses in total for 5 weeks, but may vary depending on the advice from your medial expert.

Most of the patients under medication of arsenic trioxide suffer from nausea, vomiting, abdominal pains, leukocytosis, fatigue, hyperglycemia, edema, cough, rash or itching, dyspnea, headaches and dizziness, and some drug-related toxicity -- though the latter is said to be a rare case.

There were no tests conducted in regards to the interaction of arsenic trioxide with other medications. As a safety precaution, it is advisable to consult a doctor or have a health care provider do a thorough physical and medical examination on the patient to determine the effectiveness and safety on the use of the medication. Patients who have adverse allergic reaction to arsenic should not undergo treatment using this medication.

Patients who are treated with arsenic trioxide should be monitored at least twice a week to determine abnormalities before and after the treatment. This should be a priority for clinically unstable patients.

Pregnancy Category D should have the advice of a health care provider before proceeding with the treatment. Mothers should not breastfeed their babies when under arsenic trioxide treatment to avoid complications within the infant's system. People with renal and hepatic impairment should seek or consult their doctor or physician before proceeding with the treatment.

Arsenic trioxide has the following structural formula:

Chemical structure of arsenic trioxide

• Chemical IUPAC Name is 2,4,5-trioxa-1,3-diarsabicyclo[1.1.1]pentane
• Molecular weight is 197.841 g/mol
Arsenic trioxide available : 10ml ampules

Brand name(s): Acide arsenieux, Anhydride arsenieux, Arseni trioxydum, Arsenic blanc, Arsenic oxide, Arsenic sesquioxide, Arsenicum album, Arsenigen saure, Arsenious acid, Arsenious Oxide, Arsenious Trioxide, Arsenite, Arsenolite, Arsenous Acid, Arsenous Anhydride, Arsenous Oxide, Arsentrioxide, Arsodent, Claudelite, Claudetite, Crude Arsenic, Diarsenic Trioxide, Diarsonic Trioxide, Poison Flour, Trisenox, White Arsenic

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