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Atamet

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Atamet

Atamet review





Atamet, also known as MK-486, is a decarboxylase inhibitor given to patients suffering from Parkinsons disease. It is used together with the medication Levodopa, a medication that increases the amount of dopamine in the body.

Atamet prevents Levodopa from breaking down before it reaches the central nervous system. Because of this, only a smaller dosage of Levodopa is needed, which minimizes the medication's side effects like nausea and vomiting. Atamet together with Levodopa are a medication combination used to treat Parkinson's disease, a degenerative disorder that affects the central nervous system, speech and motor skills.

By itself, Atamet does not work. It is effective only when taken in tandem with Levodopa. Both are also used for the treatment of the side effects of chlorpromazine (Thorazine), fluphenazine (Prolixin) and perphenazine (Trilafon), which can cause conditions that affect the muscles.

Atamet can cause dizziness or drowsiness and should not be taken within two hours of driving a vehicle, operating heavy machinery, or performing any activity that involves a great amount of risk.

Patients who are taking antidepressant medicaments like isocarboxazid (Marplan) and phenelzine (Nardil), and anxiety medicaments like tranycypromine (Parnate) should inform their doctor before starting Atamet-Levodopa treatment. They should also tell their doctor if they are suffering from narrow-angle glaucoma (an eye disease), or malignant melanoma (a kind of skin cancer).

Other medicaments that affect Atamet treatment include antacids, hypertension medicaments, medication used for the treatment of epilepsy like phenytoin (Dilantin), ethotoin (Peganone) and mephenytoin (Mesantoin), spasm medicaments like papaverine (Pavabid, Cerespan), and pyridoxine (Vitamin B6). Patients taking these medication will have to refrain from taking Atamet or take an adjusted dosage and undergo special monitoring while undergoing treatment.

Diabetic patients should also be aware that Atamet may affect the results of sugar and ketone urine tests, so they should inform their doctor if they are taking the medication.

Other conditions that need to be disclosed before taking Atamet include heart disease, hypertension or high blood pressure, arteriosclerosis (hardening of the arteries), irregular heartbeat, previous incidences of heart attack, respiratory diseases like asthma, liver disease, kidney ailments, hormonal diseases which affect the endocrine glands, gastrointestinal disorders such as ulcers, wide-angle glaucoma, depression and other similar psychiatric syndromes.

Patients who are pregnant, plan to become pregnant or become pregnant during treatment should inform their doctor. The effects of Atamet on the fetus are unknown, and it is advisable to use the medication with caution. Likewise, patients who are breastfeeding should let their doctor know before proceeding with treatment as Atamet may also be passed into breast milk.

Atamet, by itself, does not cause any side effects. However, when combined with Levodopa, the tandem may result in slight nausea, vomiting or loss of appetite, constipation, dry mouth or blurry eyesight, hand spasms and muscle twitches, sleep difficulties, confusion or nightmares, anxiety, fatigue, and darker sweat and urine.

If patients start experiencing severe allergic reactions like breathing difficulties or skin edema of the facial tissues, hives, uncontrollable body movements, constant nausea, vomiting and diarrhea, irregular heartbeat, unexplainable mood swings and seizures, they should immediately stop taking Atamet and seek emergency medical care as soon as possible.

Atamet is distributed under the brand name Lodosyn and comes in round, orange 25 mg. pills. In combination with Levodopa, it is also known as Sinemet, Parcopa and Stalevo. Atamet should be taken as prescribed by the doctor, usually together with Levodopa, for the medication to take effect.

Atamet has the following structural formula:

Chemical structure of atamet


• Molecular formula of atamet is C10H14N2O4
• Chemical IUPAC Name is 3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methyl-propanoic acid
• Molecular weight is 226.229 g/mol
Atamet available : 10-100mg tablets, 25-250mg tablets, 25-100mg tablets

Generic name: Carbidopa

Brand name(s): Carbidopum, Lodosin, Lodosyn, Sinemet

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