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Atropin

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Atropin

Atropin review





Atropin is a tropane alkaloid compound extracted from a variety of potentially deadly plants including deadly nightshade, mandrake and other plants in the Solanacaea family. Atropin is used in a variety of situations where the parasympathetic nervous system (PNS) is involved in inducing reactions. It blocks certain signals and lowers all muscle and gland activity controlled by the PNS. Although Atropin can be potentially deadly, the WHO ranks this drug among the essentials for maintaining a basic health care service. It is available in injections, ointments, ophthalmic (eye) solutions, and tablet formulations.

Atropin can cause increased heart rates, relaxing of smooth muscles such as those in the gut, reduction of secretions in various parts of the body such as the mouth and pupil dilation. Some small doses may slow down the heart rate as a whole.

Atropin is given to patients to control a variety of bodily functions such as dilating pupils, reducing respiratory and salivary secretions, relieving artery pressure and resumption of cardiac rate, treating ulcers by suppressing secretions, suppressing excess colon movement and bedwetting, and therapy for certain cases of cardiac arrests and bradycardia among many others.

It is also used as a treatment for cardiovascular collapse in certain poisonings and as an emergency treatment to relieve tightening airways due to asthma, chronic bronchitis and COPD.

For children, the lowest possible dosage is often given, and often corresponds to the child’s body weight – ranging from 0.1mg to 0.4mg.

Adult dosages vary as well depending on the condition being treated. Eye solutions are applied up to 4 times every day, with each dose amounting to 1 to 2 drops of 0.5% to 1% solution. Ointments may be applied twice daily. Injections may be applied intravenously, intramuscularly, or subcutaneously in doses of 0.4 to 0.6 mg every 4 to 6 hours.

Side effects of Atropin include blurring of vision, dryness of the mouth, tachycardia or increased heart rate, and some degree of photosensitivity. Mild rashes have also been observed which may lead to a degree of exfoliation in some patients after receiving a therapeutic dose. Elderly patients may experience constipation.

More severe side effects are often associated with increased and continuous doses. These may include pupil dilation (unless intended), hot and dry skin, thirstiness and difficulty to swallow, restleness, tremors, fatigue and ataxia.

Toxic doses due to an overdose can cause palpitations, excitement, delirium and even coma. In very severe cases blood pressure can drop and respiratory failure may occur, leading to death.

Care should be taken when being administered to patients over 40 years of age, while use for children is not recommended.

Atropin is very potent. Make sure to check the concentration of the Atropin medication used as multiple concentrations are available and may be easily confused for one another. Also, watch for discoloration or floating particles in the injection solutions. Do not use the solution if either is present. Intramuscular injections should also be administered in the patient’s mid-thigh region.

Atropin has the following structural formula:

Chemical structure of atropin


• Molecular formula of atropin is C17H23NO3
• Chemical IUPAC Name is (8-methyl-8-azabicyclo[3.2.1]oct-3-yl) 3-hydroxy-2-phenyl-propanoate
• Molecular weight is 289.369 g/mol
Atropin available : 5ml 1% bottles

Generic name: Atropine

Brand name(s): Atnaa, Atropair, Atropen, Atropina, Atropinol, Atropisol, Atrosulf, Equipin, Eyesules, Hyoscyamine, I-Tropine, Isopto atropine, Minims atropine, Ocu-Tropine, Tropine tropate, Troyl tropate

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