Azacitidina review

Azacitidina is a medication used to treat myelodysplastic syndrome (Myelodysplastic syndromes), as type of bone marrow disease that often precedes leukemia. This disease is manifested by improper functioning of the bone marrow. Bone marrow cells are deformed, leading to a decrease in blood production.

Azacitidina acts by improving the bone marrow function by binding to the DNA and RNA, and improving blood production by killing off abnormal cells. In a test done on Azacitidina use, patients who previously needed blood transfusions for Myelodysplastic syndromes no longer needed it after taking Azacitidina, and 16% reported full return of bone marrow structure and blood cell count.

Azacitidina is used to treat Myelodysplastic syndromes and its subtypes such as various refractory anemia, including those with ringed sideroblasts, excess blasts, and excess blasts in transformation. It is even used in the treatment of some leukemia such as chronic myelomonocytic leukemia, refractory acute lymphocytic leukemia and refractory acute myelogenous leukemia.

Azacitidina is available as a powder that is readily soluble in water and can be administered subcutaneously or intravenously by a doctor or nurse. Treatment consists of a once-a-day injection for seven days, and may be repeated after 4 weeks. Doctors usually prescribe 4 treatments at a time. However, doses may be increased after two cycles if significant improvement is not experienced and no adverse side effects are seen. Conversely, subsequent treatments may be delayed or doses reduce if adverse side effects are experienced. It is important to communicate with your doctor regarding any effects felt while undergoing treatment. The amount per dose is dependent on your weight and possibly previous treatment history and other assessments made by your doctor. The doctor may also use Azacitidina in other related conditions if it is found to work effectively on you.

Side effects of Azacitidina treatment may include nausea, diarrhea or costiveness, mouth sores, tiredness, cramps, back and joint pain, perspiration, skin edema of ankles, hands and feet, rashes and reddening of skin and weakness. A low white blood count may be experienced in between sessions and during this period you may be susceptible to infections. This low point however is temporary, lasting for 10-17 days and possibly taking 28-31 days to recover.

Other side effects are serious, and need immediate medical attention. These may include pale skin, rapid heartbeat, chest pains, bruising or bleeding, epistaxis, signs of infection such as a fever and sore throat, and red or purple dots on the skin. Consult with your doctor immediately if any of these side effects occur.

Inform you doctor of any medication you are currently taking as well as any present medication allergies you have. Also, avoid taking aspirin while undergoing treatment unless your doctor specifically allows this.

Do not receive any form of immunization such as vaccines while on Azacitidina. The lowered white blood cell count may leave you in danger.

Azacitidina may be harmful to a developing fetus if you are pregnant and may also affect fertility if you are planning to become pregnant. Contraceptives may also interact with the medication and barrier methods such as condoms are preferred. Avoid breastfeeding during this period as well.

Azacitidina has the following structural formula:

Chemical structure of azacitidina

• Molecular formula of azacitidina is C8H12N4O5
• Chemical IUPAC Name is 4-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one
• Molecular weight is 244.205 g/mol
Azacitidina available : 100mg tablets

Generic name: Azacitidine

Brand name(s): Azacitidinum, Azacytidine, Ladakamycin, Mylosar, Vidaza

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