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Azathioprin

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Azathioprin

Azathioprin review





Azathioprin is an immunosuppressant, which is used to weaken the immune system. It also goes by the brand names Imuran and Azasan and is available in pill form, as an injection, or intravenously. Azathioprin is given to patients anticipating an organ transplant or who have already been given a new organ, to help prevent rejection by the immune system. It is also given to reduce the signs and symptoms of rheumatoid arthritis, which is a disorder in which the immune system attacks the joints and causes severe pain. Azathioprin is also used to treat ulcerative colitis, a chronic condition that causes pain and diarrhoea in the intestines. Other inflammatory conditions that can be treated by Azathioprin include systemic lupus erythematosus, inflammatory myositisis, inflammatory bowel disease, and vasculitis. Typically, it takes six to eight weeks for the patient's condition to improve, though it can sometimes take up to twelve weeks.

Azathioprin has some known side effects. Most importantly, it can cause a decrease in the number of blood cells in your bone marrow. Call your doctor immediately if you have any unusual bleeding or bruising, fatigue, cephalalgia, confusion or dizziness, increased heart rate, weakness, difficulty breathing, sore throat, fever, chills, or any signs of infection. It can also increase your risk of developing some cancers, such as skin cancer and lymphoma. Let your doctor know if you have ever taken any cancer medicaments or if you find any suspicious lumps or masses on your body.

Azathioprin's common side effects include an upset stomach, emesis or diarrhoea, muscle soreness, blurred vision, mouth sores, coughing, lack of energy or appetite, flu-like symptoms, rash, or yellowing of the skin or eyes. Contact your doctor if these symptoms are severe or do not go away. While taking Azathioprin, you should be receiving regular blood tests to ensure that these side effects are not inhibiting your treatment. Some patients are not able to take Azathioprin, or may require a lower dose or special monitoring while undergoing treatment.

If you are pregnant or may become pregnant, you will want to discuss the benefits and risks of this medicament with the doctor. Studies regarding the effects of Azathioprin offer contradicting conclusions with respects to the safety of this medicament for pregnant women. Early studies indicated that Azathioprin would not cause any deformities or problems for a developing fetus, and very little risk for pregnant women or their babies. However, recent studies suggest that harm to the fetus can result from taking Azathioprin. No conclusions have been reached as to how much harm or what levels of medicament put a fetus in danger, but it is always best to err on the side of caution. Due to the uncertainty surrounding this subject, exercise extreme caution if you are pregnant and considering treatment with Azathioprin. Do not breastfeed while taking this medicament since it is a cytotoxic medicament and can be harmful to nursing babies.

Azathioprin has the following structural formula:

Chemical structure of azathioprin


• Molecular formula of azathioprin is C9H7N7O2S
• Chemical IUPAC Name is 6-(3-methyl-5-nitro-imidazol-4-yl)sulfanyl-7H-purine
• Molecular weight is 277.264 g/mol
Azathioprin available : 50mg tablets

Generic name: Azathioprine

Brand name(s): Azamun, Azanin, Azasan, Azatioprin, Azothioprine, Ccucol, Imuran, Imurek, Imurel, Muran, Rorasul

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