Baclon review

Baclon is the generic name of a medication used to treat conditions affecting the central nervous system like spinal cord injuries, spastic diplegia (a type of cerebral palsy), multiple sclerosis (a chronic inflammatory disease of the nervous system), amyotrophic lateral sclerosis (Lou Gehrig’s Disease), and trigeminal neuralgia (a painful neuropathic disorder affecting the facial muscles).

Baclon is derived from gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitters in the central nervous system. It contains substances that bind themselves to GABA receptors to decrease nerve activity in the area of the brain that controls the skeletal muscles. It is an anti-spastic agent and muscle relaxant used to loosen up skeletal muscles and prevent spastic and convulsive movements stemming from disorders of the nervous system.

Baclon is absorbed very quickly and dispersed throughout the body. It acts on the nerves of the spinal cord, eases muscle stiffness, and enables the muscles to move more easily and with less pain. It is also used in the treatment of hiccups. Before starting Baclon treatment, patients should inform their doctor if they are allergic to Baclon, or to any other medications. If they are taking other muscle relaxants, sleeping pills or tranquilizers, they should tell their doctor as well. Other pertinent information that patients should disclose include whether they have had kidney disease, epilepsy, a history of stroke or blood clots, rheumatic disease, ulcers, cerebral palsy, diabetes, Parkinson’s disease or any kind of psychiatric disorders. Any of these conditions may warrant a dosage adjustment and frequent medical monitoring while taking Baclon.

Baclon has been classified by the FDA as pregnancy category C because it may harm an unborn baby. Female patients are advised to inform their doctor if they are pregnant or plan to become pregnant during the course of treatment. Baclon may pass into breast milk and harm a nursing infant, so it is important not to administer the medication to a breastfeeding patient. Baclon also causes sleepiness, impairs judgment, decreases alertness, and causes muscle weakness. While taking this medication, patients are cautioned to avoid driving, operating any kind of machinery, or consuming alcoholic beverages, which can exacerbate these conditions. Using Baclon with tricyclic antidepressant medications like Elavil and Sinequan can reduce brain functions and weakened muscles. Baclofan should not be taken with monoamine oxidase inhibitors like Nardil and Parnate to avoid further loss of brain functions as well as low blood pressure.

To be safe, patients should update their doctor on any prescription or over-the-counter medications they are taking, including any vitamin, mineral or herbal products, as any of these can react adversely with Baclon.

Baclon’s side effects include drowsiness, dizziness, headaches, weak muscles, some nausea, constipation, and increased urination. However, if the patient starts having breathing difficulties, hives, facial swelling, confusion and hallucinations, uneven heartbeat and even seizures, emergency medical attention is required as these are signs of a severe allergic reaction to Baclon.

Baclon is available by prescription under its generic form, or under the brand names Lioresal and Kemstro. It comes in 10 to 20 mg tablets, and in a liquid solution (0.05mg/ml, 10 mg/5 ml and 10 mg/20 ml) that can be taken orally or intrathecally (injected into the spinal fluid) for patients with severe and painful spasms.

Baclon should be taken exactly as prescribed by the doctor, usually 5 mg three times a day, with or without food, as a starting dose for adults. Patients are advised to continue taking Baclon even after symptoms have decreased or ceased. Suddenly stopping treatment without proper medical management can cause withdrawal symptoms like seizures or hallucinations, high fever, increased muscle spasms and convulsions, a breakdown of the muscles, organ failure, and even death. Doctors will usually recommend a gradual decrease of medication before completely stopping Baclon treatment.

Baclon is currently under research for use in minimizing the side effects of alcohol and opium withdrawal symptoms, and to help patients recover from substance abuse cravings (such as cocaine).

Baclon has the following structural formula:

Chemical structure of baclon

• Molecular formula of baclon is C10H12ClNO2
• Chemical IUPAC Name is 4-amino-3-(4-chlorophenyl)-butanoic acid
• Molecular weight is 213.661 g/mol
Baclon available : 10mg tablets, 20mg tablets

Generic name: Baclofen

Brand name(s): Kemstro, Lioresal

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