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Benztropine

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Benztropine

Benztropine review





Benztropine is an anticholinergic drug used for treating Parkinson’s disease and related conditions such as parkinsonism, dystonia, and akathasia. Benztropine’s anticholinergic effects have been shown to have an effective and significant therapeutic value in the management of the symptoms of parkinsonism. It counteracts the effect the effect of the neurotransmitter acetylcholine and balances the levels of acetylcholine and dopamine in the body which may help reduce the symptoms of Parkinson’s disease in its early stages. It can also be used to treat movement disorders resulting from the use of other antipsychotic medication. Aside from it’s anticholinergic effect, it also has an observed antihistaminic activity approaching that of pyrilamine maleate.

It is available in tablet form in 0.5 mg, 1 mg or 2 mg dosages and is available in brand names such a Cogentin.

It is usually indicated for most forms of parkinsonism and movement disorders resulting from use of antipsychotic drugs, with the exception of tardive dyskenesia. It is also a useful part of Parkinson’s disease treatment where it helps reduce symptoms of tremors rather than the stiffness of motion. Sufferers of dystonia also benefit from benztropine as it can relax the sudden contortions of the limbs and torso that these patients can suffer.

Benztropine is often administered using the lowest dose possible, with the doctor monitoring the patient’s condition as the dosage is increased by 0.5mg every 5 to 6 days – up to a maximum dose of 6 mg. This is to find the optimal dose using the least amount of medicine.

Usually the doctor will instruct you to take the medicine 2 to 4 times each day along with meals and before sleeping or as a single dose at taken at bedtime. The doctor may modify dosage as he sees fit to your condition.

Benztropine should be taken at least an hour before taking antacids containing calcium, magnesium or aluminum. Also allow one to two hours before and after taking benztropine when taking adsorbent diarrhea medication containg pectin, kaolin or attapulgite as this may affect absorption of benztropine. If you are taking ketoconazole, do not take benztropine until two hours after the ketoconazole dose as it may interrupt with the absorption of the keotconazole.

If benztropine is being taken to counteract side effects caused by another antipsychotic medication, your doctor may tell you to take it only as necessary. The doctor may also alter the dosage of the other medications you may be taking. Follow the instructions carefully.

In rare cases, an addiction may arise from the use of this drug. Do not extend your treatment nor increase your dose. Proper stopping of treatment will be essential, but in certain cases an abrupt discontinuing of dose may aggravate certain symptoms so the doctor may design an increasingly lowered dose until you cane safely stop.

Dizziness, constipation, nausea, drowsiness and blurred vision or a dry mouth may occur as a side effect of benztropine use. The side effects may reduce as you get used to the medication, but if any of these effects worsen or persist, consult your doctor.

Inform your doctor of any occurrence of high fevers, severe stomach pain, any difficulty in passing urine, weakness or a decrease in sexual ability. However, if you feel chest pains, dizziness which results in fainting, mood swings and mental disturbances, irregular heartbeats or symptoms of extreme allergic reactions such as rashes, fever and inflammation, seek medical attention immediately.

Inform your doctors of your existing medical conditions, including heart disease, glaucoma, gastrointestinal disorders such as ulcers and blockage, liver disease, other mental and movement disorders, high blood pressure, or disorders causing difficulty in urination.

Beware of the drowsiness benztropine may cause, and avoid spending time in poorly ventilated and hot areas as some users may experience an increase in body temperature.

Benztropine has the following structural formula:

Chemical structure of benztropine


• Molecular formula of benztropine is C21H25NO
• Chemical IUPAC Name is 3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane
• Molecular weight is 307.429 g/mol
Benztropine available : 0,5mg tablets, 1mg tablets and 2mg tablets

Brand name(s): Akitan, Benzatropina, Benzatropine, Benzatropinum, Benztropine mesylate, Benztropinum, Cobrentin, Cogentin, Cogentine, Cogentinol

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