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Brinzolamide

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Brinzolamide

Brinzolamide review





Brinzolamide is defined as a carbonic anhydrase inhibitor that is commonly used to lower intraocular pressure (IOP) for patients suffering from ocular hypertension or open-angle glaucoma. The drug was developed by Alcon Laboratories and goes by the trade name Azopt.

Azopt or brinzolamide is an ophthalmic solution commonly used to decrease the pressure in the patient’s eye, a condition commonly termed as intraocular pressure (IOP). IOP is associated with open-angle glaucoma and may cause vision loss or nerve damage if left untreated.

Carbonic anhydrase inhibitor or carbonic anhydrase II has the capability to decrease the aqueous humor secretion that results to the decrease of pressure in the anterior chamber of the eye.

The dosage in using brinzolamide differs according to the condition of the patient and prescription from your health care provider. The indication commonly found in the label of the medication is for average doses for most patients. However, it may differ according to the complexity of the IOP, as well as the diagnosis from your doctor regarding your condition.

Adults are required to use 1 drop on the afflicted eye 3 times a day. There should be at least 8 hours before the next treatment. Use of brinzolamide for children depends on the prescription and advice of your doctor or health care provider.

Patients should exercise caution with the use of brinzolamide. In case of missed dose, don’t double the treatment in a single setting. It is advisable to skip the missed dose and resume with the regular schedule.

Minor side effects cause by brinzolamide includes vision problems (blurred vision), tearing, sour or bitter taste on your mouth, nausea and vomiting, dizziness, and diarrhea.

Adverse reactions to this drug are stomach pains, rashes, bruising or bleeding, and sore throat. Patients might also suffer allergic reaction to brinzolamide and might have the following effects:


• rashes
swelling
itching
• severe dizziness
• breathing problems

It is advisable to consult an expert or your health care provider if these side effects persist during or after the treatment.

Patients are advised to consult with their health care provider before using brinzolamide. The drug might have adverse reactions with other medications that you are currently using to treat your condition. In most cases, you need to inform your doctor if you’re using other ophthalmic solutions, other carbonic anhydrase inhibitors, salicylates with high doses, and painkillers.

It is also advisable to consult your doctor before using the drug. Most doctors give their patients a full medical and physical examination to avoid complications and potential risks. It is also best to inform you doctor of previous conditions, as well as the medications you are currently using to give you an accurate prescription in regards to the use of the drug. Individuals who are suffering from kidney or liver problems are advised to consult their health care provider before undergoing treatment.

Brinzolamide has the following structural formula:

Chemical structure of brinzolamide


• Molecular formula of brinzolamide is C12H21N3O5S3
• Chemical IUPAC Name is 2-ethylamino-4-(3-methoxypropyl)-5,5-dioxo-5$l^{6},7-dithia-4- azabicyclo[4.3.0]nona-8,10-diene-8-sulfonamide
• Molecular weight is 383.51 g/mol
Brinzolamide available : ophthalmic suspension 1%

Brand name(s): Azopt

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