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Bupropion

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Bupropion

Bupropion review





Bupropion is the generic name for medications such as Wellbutrin, Wellbutrin SR, Wellbutrin XL, and Zyban SR. Bupropion is commonly used to treat depressive disorders, seasonal affective disorders, and is used as a smoking cessation medication. Bupropion is a member of the family of medications known as antidepressants.

Of course bupropion is not necessarily appropriate for everyone and a thorough medical history should be evaluated before prescribing this medication. Patients who have taken an MAO inhibitor in the previous 14 days, a history of epilepsy or other seizure disorder, an eating disorder, the use of another form of bupropion, or have suddenly ceased the use of alcohol or sedatives. Patients who have heart disease, high blood pressure, a head injury, brain or spinal cord injury, liver disease, kidney disease, bipolar disorder, medicated diabetes, currently use steroids, theophylline, or medications to treat either depression or mental illness, or the recent use of street drugs, diet pills, sedatives, narcotic pain relievers, sedatives, or alcohol may not be able to take bupropion in any form or might require special monitoring while undergoing drug therapy with this medication, depending on the condition and the severity of the condition.

The American Food and Drug Administration rated bupropion as a pregnancy risk category C. This means that bupropion may cause harm or birth defects in unborn babies. This medication has shown evidence of passing through the mother’s breast milk and affecting nursing babies. Women who are pregnant or nursing or who are likely to become pregnant should not use any form of bupropion.

The side effects associated with bupropion may be severe and may require immediate emergency medical attention. Serious side effects such as allergic reactions may be life threatening. Allergic reactions present with symptoms such as facial swelling, swelling of the lips, mouth, tongue, or throat, difficulty breathing, and hives. Other serious side effects which require emergency medical attention include seizures or fast and uneven heart rate.

Less serious side effects are quite common when taking bupropion and typically do not require emergency medical care. These side effects should be reported to the prescribing physician and may require an adjustment in the dosage to make them more tolerable. Less serious side effects may include symptoms such as headaches, migraines, insomnia, nausea, vomiting, constipation, dry mouth, agitation, confusion, dizziness, tremors, weight loss, weight gain, significant changes in appetite, mild itching, mild skin rash, increased sweating, or sexual dysfunction.

Some patients experience a sensitivity, which is neither an allergy nor a side effect, but requires some degree of medical intervention, including emergency care if severe. Symptoms such as suicidal thoughts, thoughts of self harm, serious mood changes, mania, aggression, irritability, sleeplessness, anxiety, panic attacks, or a sense of hyperactivity, especially if these are new symptoms, require intervention. This medication is not appropriate for children under the age of 12, and those under the age of 18 are more likely to experience these sensitivities.

Bupropion should be taken exactly as it has been prescribed. If this medication is being used as a smoking cessation medication, it is important that the patient does not smoke after the quit date. If a dose of bupropion has been missed, it should be taken as soon as possible unless it is almost time for the next dose, in which case the missed dose should be skipped to avoid an overdose. If an overdose occurs, the patient will require immediate emergency medical attention. Overdosing will present with symptoms which are likely to include fast heart rate, uneven heart rate, hallucinations, fainting, muscle stiffness, seizures, shallow breathing, heart failure, coma, or death.

There is a risk of drug interactions associated with bupropion. A medical history which includes a current medication schedule should be taken before prescribing this medication. Patients are urged to inquire with the prescribing physician before starting any type of new medications, including those which are over the counter and vitamin and herbal supplements. Medications with a known interaction risk with bupropion include medication which cause drowsiness, medications which suppress the appetite, and medications that are used to treat depression or for smoking cessation. Mixing bupropion with an MAO inhibitor is likely to result in life threatening interactions.

Bupropion has the following structural formula:

Chemical structure of bupropion


• Molecular formula of bupropion is C13H18ClNO
• Chemical IUPAC Name is 1-(3-chlorophenyl)-2-tert-butylamino-propan-1-one
• Molecular weight is 239.741 g/mol
Bupropion available : 100mg 12 hour tablets, 150mg 12 hour tablets, 200mg 12 hour tablets, 75mg tablets, 100mg tablets

Brand name(s): Wellbatrin, Wellbutrin, Wellbutrin SR, Zyban

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