Buspirone review

Buspirone is an effective medication for moderate anxiety. It is distinct from traditional benzodiazepines and has the advantage of having no sedating actions. People may start relying on the drug for treatment of mild symptoms after knowing other possible effects and interactions.

Buspirone is an antianxiety drug the particularly targets serotonin type 1A receptors on nerves. Serotonin is a chemical in the brain responsible for mood so as the drug alters the messages passed on by the neurotransmitter, anxiety can be alleviated. Buspirone is also available in the brand name Buspimen, Narol, Sorbon, Buspar or Buspar Dividose and comes in tablet form. Unlike other antianxiety medications belonging to the benzopiazepine class, buspirone does not cause sedation.

Buspirone is generally prescribed for patients suffering from anxiety disorders. It provides short-term relief of anxiety symptoms and is usually effective for individuals with generalized anxiety in moderate cases. Severe anxiety, panic disorders and obsessive-compulsive disorders may be alleviated to an extent but not as much compared to other antipsychotic medications.

Like any other medication, buspirone can cause a series of side effects with varying intensities. Included are drowsiness, upset stomach, stomach pain, diarrhea, constipation, headache, depression, excitement, insomnia, lightheadedness, weakness or numbness, chest pain, confusion, soar throat, ringing in the ears, nervousness and fatigue. Immediate attention should be given to symptoms like skin rash, vomiting, itching, arrhythmia, unusual head or neck muscle movement and blurred vision.

Special precautions should be given to persons suffering from or having a history of kidney or liver disease. Buspirone is contraindicated to people who have known hypersensitivity reactions to the drug or other medications or food. Pregnant women and breastfeeding mothers should first consult their physician before taking. Children as well should be guided accordingly to ensure proper consumption. People taking medications, drinking alcohol and taking caffeine should inform their doctor to know any interaction that might affect the drug’s efficacy.

Buspirone is thought to interfere with serotonin function in the brain through its partial agonistic action on the 5-HT1A receptor. It also has agonist and antagonistic actions on dopamine receptors plus some indirect actions on other brain chemicals. As serotonin and dopamine levels are improved in the brain, people suffering from anxiety will experience relief and relaxation.

30 patients suffering from moderate anxiety were given 10 mg of buspirone twice a day for 2 weeks. These patients were not given any antipsychotic drugs including benzodiazepines prior to treatment. After the first week, 24 patients showed improved mood and relief. Within the second week, 28 out of 30 were considered emotionally stable while the other two improved from moderate to mild anxiety.

Buspirone is available in pharmacies and doctor’s clinics. Be sure to check the expiry date, manufacturer and location of manufacturer. When buying online, verify the source first to be sure about the quality and freshness.

Recommended dosage for buspirone is 10 mg to 15 mg twice or thrice daily. Since it is less potent compared to benzodiazepines, benzodiazepines are usually given first. Buspirone works well when co-treated with benzodiazepines in patients with social phobias and panic attacks.

Buspirone has the following structural formula:

Chemical structure of buspirone

• Molecular formula of buspirone is C21H31N5O2
• Chemical IUPAC Name is 8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione
• Molecular weight is 385.503 g/mol
Buspirone available : 5mg tablets, 7.5mg tablets, 10mg tablets, 15mg tablets, 30mg tablets

Brand name(s): Ansial, Ansiced, Anxiron, Axoren, Bespar, BuSpar, Buspimen, Buspinol, Buspirona, Buspironum, Buspisal, Censpar, Lucelan, Narol, Travin

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