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Busulfex

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Busulfex

Busulfex review





Busulfex is a common cancer medication that is known to slow down the neoplastic activity of malignant cells. More specifically, it is a generic and non-specific cell type alkylating antineoplastic agent. It was initially created as a therapeutic medication for chronic myeloid leukemia, and has been reclassified to a generic acting medication for cancer cells.

The medication is supposed to be able to control the burden of tumor formation and significantly slow down metastasis of the cancer cells to other regions in the body. However, it is not able to fully impede the progress of it, as it is incapable of reversing the overall cellular aberration effects of the cancer cells. Cytogenic abnormalities still continue to progress in this manner, but at a slower rate than without medication.

Busulfex is given to typical cancer patients who are susceptible to chemotherapy and medication induction therapy. The mechanism of the medication in a cellular level is characterized by the production of Guanine-guanine strands of genetic output as the medication attacks the carbon strand in the mesylate group in a malignant cancer cell. This occurs in large success rates for the target cancer cell and results to an apoptotic state. However, the result may also generally decrease overall strength as massive cellular destruction on the target area is occurring as evidenced by destruction of normal cells, especially in bone marrows.

It is also an alternative option for non-operative stem cell transplantation, therefore increasing receptivity for an oncoming transplant of stem cells.

Cancer patients should have proper information regarding the effects of the medication with the proper supervision and expertise of a qualified doctor.

Busulfex is considered a palliative medication in dosages of 60 micrograms per body weight in kilos, with a maximum of 4 milligrams per day. For treatment of Polycythemia vera, 4 to 6 milligrams is recommended per day over a course of 4 to 6 weeks. For essential thrombocythaemia, 2 to 4 milligrams per day is recommended. Conditioning therapeutic medication plans call for about 3.5 to 4 milligram per body weight in kilos per day, given in four doses, totaling 14 to 16 milligrams per kilo body weight.

Side effects for Busulfex medication may include general toxicity leading to fibrosis in the pulmonary tract, seizures, wasting of the muscles and organs, and cases of liver malfunction and failure. As for the seizures, phenytoin medication may be used to lessen the occurrence.

It is important to let your doctor know the medications already being used to determine possible medication-to-medication interactions. With special consideration given to antifungal medications such as azole variants. It also is contraindicated with acetaminophens, phenothiazines and other cancer medications such as cyclosporine.

If contraindications of medications is suspected or determined, it is advisable to take medication and cautiously use the product three days after last previous medication is used.

Acetaminophen is not to be used alongside Busulfex since it raises blood levels and may increase the risk of complicated hypertension.

Busulfex has the following structural formula:

Chemical structure of busulfex


• Molecular formula of busulfex is C6H14O6S2
• Chemical IUPAC Name is 1,4-bis(methylsulfonyloxy)butane
• Molecular weight is 246.304 g/mol

Generic name: Busulfan

Brand name(s): Busulphan, Busulphane, Buzulfan, Citosulfan, Leucosulfan, Mablin, Mielevcin, Mielosan, Mielucin, Milecitan, Mileran, Misulban, Mitosan, Mitostan, Myeleukon, Myeloleukon, Myelosan, Mylecytan, Myleran, Sulfabutin, Sulphabutin

  Your Busulfex review