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Busulphan

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Busulphan

Busulphan review





Busulphan, a common cancer medicament, is known to slow down the neoplastic activity of malignant cells. More specifically, it is a generic and non-specific cell type alkylating antineoplastic agent that was initially created as a therapeutic medicament for chronic myeloid leukemia and has been reclassified to a generic acting medicament for cancer cells.

The medicament is supposed to control the burden of tumor formation and significantly slow down metastasis of cancer cells to other regions in the body. However, it is not able to fully impede the progress of the cancer cells, as it is incapable of reversing the overall cellular aberration effects of the cancer cells. Cytogenic abnormalities still continue to progress, but at a slower rate than without the medicament.

Busulphan is given to cancer patients who are susceptible to chemotherapy and medicament induction therapy. The medicament works in a cellular level by the production of Guanine-guanine strands of genetic output as the medicament attacks the carbon strand in the mesylate group in a malignant cancer cell. This occurs in large success rates for the target cancer cell and results to an apoptotic state. The result may also generally decrease overall strength as massive cellular destruction on the target area is occurring as evidenced by destruction of normal cells, especially in bone marrows.

Busulphan is also an alternative option for non-operative stem cell transplantation, therefore increasing receptivity for an oncoming transplant of stem cells.

Cancer patients should have proper information regarding the effects of the medicament with the proper supervision and expertise of a qualified doctor.

Busulphan is considered a palliative medicament in doses of 60 micrograms per body weight in kilos, with a maximum of 4 milligrams per day. For treatment of Polycythemia vera, 4 to 6 milligrams is recommended per day over a course of 4 to 6 weeks. For essential thrombocythaemia, 2 to 4 milligrams per day is recommended. Conditioning therapeutic medicament plans call for about 3.5 to 4 milligram per body weight in kilos per day, given in four doses, totaling 14 to 16 milligrams per kilo body weight.

Side effects for Busulphan medicament may include general toxicity leading to fibrosis in the pulmonary tract, seizures, wasting of the muscles and organs, and cases of liver malfunction and failure. As for the seizures, phenytoin medicament may be used to lessen the occurrence.

It is important to let your doctor know the medicaments already being used to determine possible medicament-to-medicament interactions. With special consideration given to antifungal medicaments such as azole variants. It also is contraindicated with acetaminophens, phenothiazines and other cancer medicaments such as cyclosporine.

If contraindications of medicaments is suspected or determined, it is advisable to take medicament and cautiously use the product three days after last previous medicament is used.

Acetaminophen is not to be used alongside Busulphan since it raises blood levels and may increase the risk of complicated hypertension.

Busulphan has the following structural formula:

Chemical structure of busulphan


• Molecular formula of busulphan is C6H14O6S2
• Chemical IUPAC Name is 1,4-bis(methylsulfonyloxy)butane
• Molecular weight is 246.304 g/mol

Generic name: Busulfan

Brand name(s): Busulfex, Busulphane, Buzulfan, Citosulfan, Leucosulfan, Mablin, Mielevcin, Mielosan, Mielucin, Milecitan, Mileran, Misulban, Mitosan, Mitostan, Myeleukon, Myeloleukon, Myelosan, Mylecytan, Myleran, Sulfabutin, Sulphabutin

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