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Busulphane

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Busulphane

Busulphane review





Busulphane, a common cancer medication, is known to slow down the neoplastic activity of malignant cells. More specifically, it is a generic and non-specific cell type alkylating antineoplastic agent that was initially created as a therapeutic medication for chronic myeloid leukemia and has been reclassified as a generic medication for cancer cells.

This medication is supposed to control the burden of tumor formation and significantly slow down metastasis of cancer cells to other regions in the body. It is not able to fully impede the progress of the cancer cells, as it is incapable of reversing the overall cellular aberration effects of the cancer cells. Cytogenic abnormalities still continue to progress, but at a much slower rate than without the medication.

Busulphane is given to cancer patients that are susceptible to chemotherapy and medication induction therapy. The medication works on a cellular level by producing Guanine-guanine strands of genetic output as the medication attacks the carbon strand in the mesylate group in a malignant cancer cell. This occurs in large success rates for the target cancer cell and results in an apoptotic state. The result may also decrease overall strength as massive cellular destruction on the target area is occurring as evidenced by destruction of normal cells, especially in bone marrows.

Busulphane is an alternative option for non-operative stem cell transplantation, therefore increasing receptivity for an oncoming transplant of stem cells.

Cancer patients should have proper information regarding the effects of the medication and the proper supervision and expertise of a qualified doctor.

Busulphane is considered a palliative medication in dosages of 60 micrograms per body weight in kilos, with a maximum of 4 milligrams per day. For treatment of Polycythemia vera, 4 to 6 milligrams is recommended per day over a course of 4 to 6 weeks. For essential thrombocythaemia, 2 to 4 milligrams per day is recommended. Conditioning therapeutic medication plans call for about 3.5 to 4 milligram per body weight in kilos per day, given in four doses, totaling 14 to 16 milligrams per kilo body weight.

Side effects for Busulphane medication may include general toxicity leading to fibrosis in the pulmonary tract, seizures, wasting of the muscles and organs, and cases of liver malfunction and failure. As for the seizures, phenytoin medication may be used to lessen the occurrence.

It is important to let your doctor know the medications already being used to determine possible medication-to-medication interactions. Special consideration must be given to antifungal medications such as azole variants. It also is contraindicated with acetaminophens, phenothiazines and other cancer medications such as cyclosporine.

If contraindications of medications is suspected or determined, it is advisable to take medication and cautiously use the product three days after last previous medication is used.

Acetaminophen is not to be used alongside Busulphane since it raises blood levels and may increase the risk of complicated hypertension.

Busulphane has the following structural formula:

Chemical structure of busulphane


• Molecular formula of busulphane is C6H14O6S2
• Chemical IUPAC Name is 1,4-bis(methylsulfonyloxy)butane
• Molecular weight is 246.304 g/mol

Generic name: Busulfan

Brand name(s): Busulfex, Busulphan, Buzulfan, Citosulfan, Leucosulfan, Mablin, Mielevcin, Mielosan, Mielucin, Milecitan, Mileran, Misulban, Mitosan, Mitostan, Myeleukon, Myeloleukon, Myelosan, Mylecytan, Myleran, Sulfabutin, Sulphabutin

  Your Busulphane review