Calcipotriene review

Calcipotriene is a United States adopted name for the same drug internationally known as Calcipotriol. It is the marketed generic name for the Vitamin D3 derivative in the US and is used for the treatment of psoriasis in different areas of the body. Skin rashes and plaques are effective targets and are usually treated within a few days to several weeks of calcipotriene therapy.

The drug is administered topically, in ointment, cream, or solution form and is directly applied to the afflicted area. Its mechanism of action is to affect the susceptibility of the Vitamin D receptor. As a steroid receptor, calcipotriene is able to increase effectivity of the immune system's T cell activity, therefore increasing autoimmunity and ultimately decreasing the occurrence of psoriasis, which is the manifestation of a decrease in autoimmune response.

It is classified as a psoriasis, seborrhea and ichthyosis drug.

Calcipotriene is used for the treatment of psoriasis and similar outcomes. Initial clinical tests for osteoporosis have paved the way for treatment of psoriasis when the drug accidentally or unexpectedly caused for the psoriasis rashes to disappear.

All variants of psoriasis, even those occurring at the nails may be administered with the drug. Common occurrences of psoriasis are at the back, elbows, popliteal joints, and inguinal areas. It is also applicable with scalp area infection as well.

For indirect application and treatment, it may be used to effectively cure itching caused by scaly rashes suspected to be caused by autoimmunity, and non-fungal reasons.

Calcipotriene administration is through topical application and besides seemingly harmless administration, caution and dosage adherence should be observed. Physicians commonly advise dosages of 1 to 1 times application daily, with a maximum of 100mg per week for adults, down to 50mg per week dose for under the age of thirteen. Most application mediums are in .005% composition.

For instances of forgotten or deferred dosages wherein application may be near the next scheduled application, it is highly advised not to double the application and dose for that specific schedule. It is advisable to skip the missed application and instead continue normal dosage application.

Besides the expected incidences of occasional skin itching, hyperactivity of rash spread, and over scaling of the plaques on afflicted areas, there is no known systemic effect associated with over usage of calcipotriene. Being a vitamin D component derivative, it is a naturally occurring substance in the body and has been found not to have any side effects related to internal reaction.

The mechanism of action of the calcipotriene drug is not found to have any known drug interactions that may alter the effective therapeutic result.

Precautionary measures are still highly advised to be observed, especially for pregnant and nursing mothers, as it is highly speculated that calcipotriene is able to pass through the membrane and seep to breast milk. This in turn, becomes highly risky for the neonate, as it is not prescribed.

Contraindications are given to those who have hypersensitivity to the drug or any components included in the topical solution. There are special precautions to those who have over reactivity to Vitamin D as toxicity may happen, accompanied with hypercalcemia.

Calcipotriene has the following structural formula:

Chemical structure of calcipotriene

• Molecular formula of calcipotriene is C27H40O3
Calcipotriene available : cream 0.005%

Brand name(s): Dovonex

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