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Captopril

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Captopril

Captopril review





Captopril is an angiotensin-converting enzyme inhibitor. It is indicated for the treatment of hypertension (high blood pressure) and cases of congestive heart failure. It keeps angiotensin, a chemical in the blood, from metabolizing into a dangerous substance that allows the body to retain more salt and water, leading to hypertension and eventual heart failure.

Captopril also works by relaxing the blood vessels and enabling blood to flow more freely throughout the body. It can be used by itself or taken with diuretics in the treatment of high blood pressure. For management of congestive heart failure, it is usually combined with both digitalis and diuretics.

This drug is further used to treat kidney disorders in diabetic patients. It reduces the risk of further cardiac arrest in patients who have previously had a heart attack, and can improve the chances of survival after a heart failure.

Captopril has also been prescribed for the treatment of angina pectoris (a crushing chest pain), rheumatoid arthritis, and Raynaud's phenomenon (a blood vessel disorder).

Patients who are allergic to Captopril or any of its ingredients, women who are in the second or third trimester of their pregnancy (Captopril can cause fetal death), people who have a history of allergies to ACE inhibitors, and those who are taking dextran sulfate should not take Captopril.

Before taking Captopril, patients should tell their doctor if they have any medical conditions that involve food, medicine or substance-related allergies; if they have a history of bone marrow depression, high blood potassium levels or low blood sodium levels; if they have a history of kidney disease, or if they are currently undergoing dialysis or have had a previous kidney transplant; if they have a history of heart disease; if they have the autoimmune disease, lupus; if they are on a sodium-restricted diet , or if they are breastfeeding.

Captopril may affect the results of some laboratory tests such as urine ketone tests of diabetes sufferers. As Captopril may also cause adverse reactions when taken with certain drugs, it is advisable for patients to inform their doctor of all the medications, including vitamin, mineral and herbal supplements they may be taking.

Some of the medications which counteract with Captopril include dextran sulfate (Allopurinol), which can cause allergic reactions; diurectics, which increases the risk of low blood pressure and low blood sodium; NSAIDs (nonsteroidal anti-inflammatory drugs), which can lower the effectiveness of Captopril; Lithium or thiopurines; oral diabetes drugs, which may lower blood sugar levels, and Potassium supplements, which may further increase blood potassium levels.

Captopril may also cause adverse reactions like coughing, a rash, and a metallic taste in the mouth. In some cases, patients on Captopril may experience hypotension, a condition where blood pressure becomes abnormally low, and hyperkalemia, which is indicated by excessive potassium in the blood.

Other side effects include dizziness or lightheadedness, which may be aggravated by alcohol consumption; fainting; fatigue; diarrhea; vomiting; headaches; itching and fever. If the patient experiences severe allergic reactions like hives, itching, breathing difficulties, swelling of the facial tissues, jaundice, irregular heartbeat, fainting and signs of infection like fever and sore throat, they should discontinue all use of Captopril and seek emergency medical attention immediately.

Captopril is distributed by Bristol-Myers Squibb under the brand names Capoten or Inhibace. It also comes under another brand, Capozide. Depending on the patient's condition and doctor's prescription, Captopril should be taken orally on an empty stomach, an hour before meals. For high blood pressure, diabetes-related kidney ailments, and for patients recovering from heart failure, the usual dosage is 25 mg., 2 to 3 times a day. Patients who have just suffered a heart attack are usually give an initial 6.25 mg. dose once, followed by 12.5 mg. 3 times a day. Captopril use should not exceed 450 mg. daily to prevent drug overdose.

Captopril has the following structural formula:

Chemical structure of captopril


• Molecular formula of captopril is C9H15NO3S
• Chemical IUPAC Name is (2S)-1-[(2S)-2-methyl-3-sulfanyl-propanoyl]pyrrolidine-2-carboxylic acid
• Molecular weight is 217.286 g/mol
Captopril available : 12.5mg tablets, 25mg tablets, 50mg tablets, 100mg tablets

Brand name(s): Acediur, Aceplus, Acepress, Acepril, Alopresin, Apopril, Capoten, Capozide, Captolane, Captoprilum, Captopryl, Captoril, Cesplon, Dilabar, Garranil, Hipertil, Hypertil, L-Captopril, Lopirin, Lopril, Tenosbon, Tensobon, Tensoprel

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