Captoprilum review

Captoprilum, an angiotensin-converting enzyme inhibitor, is used to treat hypertension (high blood pressure) and cases of congestive heart failure. It keeps a chemical in the blood, angiotensin, from metabolizing into a dangerous substance that allows the body to retain more salt and water, which leads to hypertension and eventual heart failure.

Captoprilum works by relaxing the blood vessels and enabling blood to flow more freely throughout the body. It can be used alone or with diuretics in the treatment of high blood pressure. For treating congestive heart failure, it is combined with both digitalis and diuretics.

This medication can also be used to treat kidney disorders in diabetic patients. It reduces the risk of cardiac arrest in patients that have previously had a heart attack and can improve the chance of survival after heart failure.

Also, Captoprilum can be used in the treatment of angina pectoris (a crushing chest pain), rheumatoid arthritis, and Raynaud's phenomenon (a blood vessel disorder).

Patients allergic to Captoprilum or any of its ingredients, women in the second or third trimester of pregnancy (Captoprilum can cause fetal death), patients with a history of allergies to ACE inhibitors, and those taking dextran sulfate should avoid Captoprilum.

Patients need to talk with their physician regarding any medical conditions including food, medicine or substance-related allergies, a history of bone marrow depression, high blood potassium levels or low blood sodium levels, a history of kidney disease, or if they are currently undergoing dialysis or have had a previous kidney transplant, a history of heart disease, the autoimmune disease, lupus, a sodium-restricted diet, or if they are breastfeeding.

Captoprilum can affect the results of some laboratory tests such as urine ketone tests. Captoprilum may cause negative reactions when taken with certain medications, so patients need to inform their physician of all medications, including vitamin, mineral and herbal supplements they may be taking.

Some medications known to interact with Captoprilum include dextran sulfate (Allopurinol), which causes allergic reactions; diurectics, which increases the risk of low blood pressure and low blood sodium; NSAIDs (nonsteroidal anti-inflammatory medications), which can lessen the effectiveness of Captoprilum; Lithium or thiopurines; oral diabetes medications, which may lower blood sugar levels, and Potassium supplements, which may increase blood potassium levels.

Captoprilum has caused adverse reactions including coughing, a rash, and a metallic taste in the mouth. Some patients may experience hypotension, a condition where blood pressure becomes abnormally low, and hyperkalemia, indicated by excessive potassium in the blood.

Other known side effects include dizziness or lightheadedness, which can be aggravated by alcohol consumption; fainting; fatigue; diarrhea; vomiting; headaches; itching and fever. If the patient experiences an allergic reaction including hives, itching, breathing difficulties, swelling of the facial tissues, jaundice, irregular heartbeat, fainting and signs of infection like fever and sore throat, discontinue use of Captoprilum and immediately seek emergency medical attention.

Captoprilum is distributed by Bristol-Myers Squibb under the brand names Capoten and Inhibace. Depending on the patient's condition and the prescription, Captoprilum is taken orally on an empty stomach an hour before meals. For high blood pressure, diabetes-related kidney ailments, and patients recovering from heart failure, the typical dosage is 25 mg., 2 to 3 times a day. Patients recovering from a heart attack are typically given an initial 6.25 mg. dose, followed by 12.5 mg., 3 times a day. Patients should not exceed 450 mg.of Captoprilum daily to prevent an overdose.

Captoprilum has the following structural formula:

Chemical structure of captoprilum

• Molecular formula of captoprilum is C9H15NO3S
• Chemical IUPAC Name is (2S)-1-[(2S)-2-methyl-3-sulfanyl-propanoyl]pyrrolidine-2-carboxylic acid
• Molecular weight is 217.286 g/mol
Captoprilum available : 12.5mg tablets, 25mg tablets, 50mg tablets, 100mg tablets

Generic name: Captopril

Brand name(s): Acediur, Aceplus, Acepress, Acepril, Alopresin, Apopril, Capoten, Capozide, Captolane, Captopryl, Captoril, Cesplon, Dilabar, Garranil, Hipertil, Hypertil, L-Captopril, Lopirin, Lopril, Tenosbon, Tensobon, Tensoprel

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