Carbamazapine review

Carbamazapine is used to prevent ulcers in the stomach and small intestines, gastroesophageal reflux disease, upper GI bleeding and acid reflux. Other uses include: the prevention of aspiration of inflammatory illness of the lung and stress ulcers, and herpes virus infection and this medication can be used prior to anesthesia to prevent aspiration pneumonitis.

Carbamazapine works by blocking histamine, which is responsible for releasing acid into the stomach. Tagamet is the brand name for this medication and it is available in tablet or liquid form. Carbamazapine is taken orally with or without food. It is not recommended to take an antacid one hour before or after taking this medication. Cephalosporin, itraconazole and ketoconazole should be taken two hours prior to taking Carbamazapine. If a dose is missed, take it as soon as remembered, but do not take more medication to make up for missed doses and do not take more than one dose at a time.

Carbamazapine is classified by the FDA as pregnancy category B. It has been proven that this medication can be excreted in breast milk. It is imperative the prescribing physician be notified if the patient is pregnant or plans to become pregnant. The physician should also be notified if the patient is allegeric to any ingredients in Carbamazapine. Extreme caution should be used when prescribing this medication to the elderly, as they may have reduced renal function. Caution is also necessary when prescribing this medication to children under 16, as the medication has not been established for safety and efficacy for this age group.

There are some medication and dietary interactions that can occur while taking this medication. A patient taking medicine for cancer, asthma, high blood pressure, erectile dysfunction or if they are taking cisapride, dofetilide or nitrosoureas cannot take this medication. Antacids, anticholinergics, or metoclopramide may inhibit the body from properly adsorbing the Carbamazapine. Carbamazapine may reduce the effectiveness of these medications: tricyclic antidepressants, calcium channel blockers, quinine and caffeine. If taken with carmustine there is a possibility that bone marrow toxicity will be enhanced. This medication will not interfere with lab testing. Patients should not take over-the-counter medications, herbal medicines or dietary supplements without the prescribing physician's knowledge. Some counseling regarding lifestyle changes, stress reduction and dietary changes (no spicy foods or alcohol) is recommended. Laboratory testing and follow-up visits will be important to monitor the effectiveness of the medication. Smoking cessation is highly recommended as smoking will reduce the ulcer healing efficacy of Carbamazapine.

Several side effects may occur while taking this medication. Dizziness and drowsiness can occur and patients should not drive or perform highly complicated tasks until they know how they will be affected while on this medication. If there is any black tarry stool, abdominal pain, confusion or coffee-ground emesis, the physician should be notified immediately. Severe side effect can include: breast enlargement or lumps, mood condition, agitation, diarrhea, bronchospasm, fatigue, hallucinations, hair loss, joint or muscle pain, loss of libido or cardiac arrhythmias. If an overdose of the medication is suspected, the patient should be immediately taken to the emergency room or contact a local poison control center. An overdose may present with a variety of symptoms including but not limited to nausea, emesis with coffee ground substance, hallucinations, diarrhea, and severe mood condition or emotional disturbance.

Carbamazapine has the following structural formula:

Chemical structure of carbamazapine

• Molecular formula of carbamazapine is C10H16N6S
• Chemical IUPAC Name is 1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]guanidine
• Molecular weight is 252.34 g/mol
Carbamazapine available : 300mg tablets, 400mg tablets

Generic name: Cimetidine

Brand name(s): Acibilin, Acinil, Cimal, Cimetag, Cimetum, Dyspamet, Edalene, Eureceptor, Gastromet, Peptol, Tagamet, Tametin, Tratul, Ulcedin, Ulcedine, Ulcerfen, Ulcimet, Ulcofalk, Ulcomedina, Ulcomet, Ulhys

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