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Carvedilol

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Carvedilol

Carvedilol review





Carvedilol belongs to a group of drugs called beta-blockers, which affect the heart and blood flow within the veins and arteries. Carvedilol is a non-selective beta blocker, which means that it blocks both beta 1 (responsible for heart rate and heartbeat strength) and beta 2 (responsible for smooth muscle functions) receptors.

Carvedilol is a generic drug distributed under the brand names Dilatrend, Eucardic, Coreg and Coreg CR. It is used for the treatment of mild to moderate congestive heart failure (CHD). It is also indicated for hypertension, or high blood pressure, and as treatment and for prevention of heart attacks.

Carvedilol works by slowing the heart’s rhythm and lowering the heart’s pumping force. It also relaxes the blood vessels enabling the blood to travel through the veins and arteries without difficulty. In doing so, blood pressure is lowered and the risk for heart failure is reduced.

Patients should inform their doctor if they have a history of allergies to the drug, as well as if they are suffering from asthma, bronchitis or emphysema, slow or irregular heartbeat, or liver disease, conditions which may worsen with Carvedilol use. Patients should also tell their doctor if they have diabetes, low blood sugar, low blood pressure, hyperthyroidism (an excess of thyroid hormones), Prinzmetal’s angina (unexplained chest pain), or pheochromocytoma (tumors in glands near the kidneys).

The doctor should also be apprised of any prescription or over-the-counter medications, including vitamin, mineral and herbal supplements that the patient may be taking, as they may cause adverse effects when taken with Carvedilol. Other counterindications include undergoing surgery, consuming alcoholic beverages or taking any medications containing alcohol, and driving a car or operating heavy machinery within two hours after taking the medication.

Women who are pregnant, or become pregnant while taking Carvedilol must inform their doctor immediately. This drug has been classified by the FDA under pregnancy category C, which means that it is harmful to an unborn baby. It can also harm nursing infants. Women who are nursing should refrain from taking Carvedilol without notifying their doctor.

Patients taking Carvedilol may experience episodes of dizziness, lightheadness, and even fainting. Another side effect is hyperglycemia, or high blood sugar. Excessive thirst, frequent urination, extreme hunger, weakness and blurred vision are symptoms of hyperglycemia. If patients taking Carvedilol exhibit any of these symptoms, they should call their doctor as soon as possible.

Other side effects include weakness and fatigue, headaches, nausea, vomiting, diarrhea, joint pain, insomnia, coughing, dry eyes, changes in vision, and numbness or tingling of the arms or legs. Side effects like fainting, breathing and swallowing difficulties, weight gain, chest pain, swelling of the arms and legs, rashes, hives, itching, and slow or irregular heartbeat are considered serious and need immediate medical attention.

Carvedilol comes in white, oval, film-coated tablets of different milligram dosages, and extended release capsules. In tablet form, the prescribed dose is two times a day to be taken with food. Carvedilol in extended release capsules is taken once a day with food, usually in the mornings. The medication should be taken whole, not crushed, chewed or ground, at the same time each day with a full glass of water.

Carvedilol can control symptoms, but cannot eliminate the condition altogether. This drug is merely one of the elements in a comprehensive treatment program that may include a special diet, exercise and proper weight control. Patients are advised to take Carvedilol regularly, sometimes for the rest of their lives. Suddenly going off the medication without prior medical advise can cause severe chest pain, irregular heartbeat, and even a heart attack.

Carvedilol has the following structural formula:

Chemical structure of carvedilol


• Molecular formula of carvedilol is C24H26N2O4
• Chemical IUPAC Name is 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol
• Molecular weight is 406.474 g/mol
Carvedilol available : 3.125mg tablets, 6.25mg tablets, 12.5mg tablets, 25mg tablets

Brand name(s): Carvedilolum, Coreg

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