Cefaclor review

Cefaclor is the generic name for a second-generation broad-spectrum antibiotic from the group of antibacterial drugs known as cephalosporins. It is available under the brand names Ceclor, Ceclor CD, Ceclor Pulvules, and Raniclor.

Cefaclor is usually indicated for the treatment of bacterial infections like pneumonia, and infections of the ear, lung, skin, throat, and urinary tract. It works by penetrating the body’s tissues and fluids, and obstructing the growth of the bacteria causing the infection.

Patients should not take Cefaclor if they are allergic to cephalosporin, penicillin or other antibiotics, or if they have a kidney disorder or any digestive disease like colitis. They are advised to inform their doctor of these illnesses to get a prescription for a different dosage and constant monitoring during the course of treatment.

In suspension form, Cefaclor contains sucrose, which is not an advisable for diabetics. Pregnant women or those planning to get pregnant should upraise their doctor of their situation before treatment. As Cefaclor can be passed on to breast milk, nursing mothers need to tell their doctor if they are breastfeeding before taking any dose of the medication, so as not to affect nursing infants.

Patients are advised not to take antacids that contain magnesium or aluminum while under Cefaclor treatment as these can lower the efficacy of the antibiotic. Some examples of these antacids are Rolaids, Maalox, Mylanta, and Milk of Magnesia. Other drugs that may affect Cefaclor include Warfarin (an anticoagulant), Probenecid (an arthritis and gout drug), loop diuretics or water pills, and other antibiotics. Patients should inform their doctor of any other medications, vitamin or herbal supplements they may be taking prior to starting their Cefaclor treatment.

Cefaclor side effects include allergic reactions in the form of rashes, itching, uticaria (hives), fever, serum sickness-like reactions (hypersensitivity), arthralgia (joint paint), and anaphylaxis (whole body allergy). Patients may also experience diarrhea, nausea, vomiting, stomach upset, transient hepatitis, jaundice, headaches and Stevens-Johnson syndrome (a deadly allergic skin disease). In some rare cases, blood disorders, nephritis (kidney inflammation), hyperactivity, nervousness, disrupted sleep, hallucinations, confusion and dizziness may occur.

Patients should immediately stop taking Cefaclor and seek emergency medical attention if they experience severe allergic reactions like breathing difficulties, swelling of the facial tissues, rashes, redness or itching, nausea, vomiting or diarrhea, blood or mucus in their stools, or unexplained bleeding and bruising. In any case, all side effects should be reported to the doctor for evaluation, particularly if they interfere with day to day activities.

Cefaclor comes in purple and white 250 mg. capsules, purple and gray 500 mg. capsules, and as a suspension (liquid) in strawberry flavor. Ceclor CD is also manufactured in blue tables of 375 and 500 mgs. When taking Cefaclor in liquid form, the bottle needs to shaken and the correct dosage accurately measured out using a measuring spoon or cup.

Cefaclor can be taken with a full glass of water on a full or empty stomach. Ceclor CD, in extended release capsules, however, needs to be ingested with food or milk to prevent stomach upset. Ceclor CD tablets are specially created to be released slowly in the body, so it is advisable not to cut, grind or chew them.

While symptoms of an infection usually disappear early on, the bacteria causing the infection may still remain in the body. Cutting the medication process short may cause the body to develop a resistance to antibiotics.

Cefaclor needs to be taken regularly during the prescribed period to make sure the body has contains a consistent level of the drug, and to obtain the best effect from it. Any unused medication should be disposed of after 14 days.

Cefaclor has the following structural formula:

Chemical structure of cefaclor

• Molecular formula of cefaclor is C15H14ClN3O4S
• Chemical IUPAC Name is (6R,7R)-7-[(2-amino-2-phenylacetyl)amino]-3-chloro-8-oxo-5-thia-1- azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• Molecular weight is 367.8074 g/mol
Cefaclor available : 250mg capsules, 500mg capsules, 187mg/5ml suspension 100ml bottle, 375mg/5ml suspension 100ml bottle, 125mg/5ml suspension 150ml bottle, 250mg/5ml suspension 150ml bottle, 187mg/5ml suspension 50ml bottle, 375mg/5ml suspension 50ml bottle, 125mg/5ml suspension 75ml bottle, 250mg/5ml suspension 75ml bottle

Brand name(s): Alenfral, Alfacet, Alfatil, Ceclor, Ceclor CD, Cefaclorum, Cephaclor, Distaclor, Kefral, Panacef, Panoral, Raniclor

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