Cefepimum review

Cefepimum, an antimicrobial medication, is classified under fourth generation cephalosporin antibiotics, which is often used to treat moderate to severe pneumonia and other bacterial infections. Cefepimum is rarely used due to a Food & Drug Administration communication regarding its safety. The article, Efficacy and Safety of Cefepimum: A Systematic Review and Meta-analysis, was published in May 2007 in The Lancet Infectious Diseases. It is about an ongoing review of Cefepimum's effectiveness and an increased mortality rate connected to its use.

Cefepimum was developed in early 1990s and marketed in 1994 under numerous trade names and has been found effective in treating both Gram-positive and Gram-negative organisms. Aside from pneumonia and other respiratory infections, Cefepimum is also used to treat complicated episodes of urinary tract infections, skin infections, and intra-abdominal infections. It is often used as an Empiric Therapy for Febrile Neutropenic Patients. The effectiveness of Cefepimum over other antibacterial medications lies in its activity against susceptible bacteria.

Cefepimum is a liquid suspension given intravenously. It is injected into your large muscle in the hip, in the buttock or added to an intravenous fluid every 12 to 24 hours. Doctor supervision is significant in Cefepimum use because the doctor is the only one who can tell you whether it is appropriate to treat your current disease or not. A patient on Cefepimum treatment is also closely watched to ensure that the effectiveness of the medication is greater than its side effects. Physical examinations and laboratory testing are used to monitor how the patient's symptoms respond to the treatment.

The dosage for an adult per day and duration depend on the severity of their affliction as well as their medical history. Dosage adjustments are necessary for people with particular conditions. You must openly talk with your doctor regarding your medical history. Patients who have allergies, are currently taking other medicines, have had bouts with kidney, liver, and gastrointestinal diseases, are pregnant, are planning to become pregnant or have diabetes are especially looked at. It is important for a patient's safety to follow the prescription closely. Do not alter it without the knowledge of your doctor. Ceasing to take Cefepimum due to an early improvement of your symptoms might give the bacteria enough space to thrive and cause more damage.

Cefepimum may cause diarrhoea, stomach pain, and vomiting as side effects. If these symptoms persist or worsen as you continue with the treatment, call your doctor immediately. Skin rash, breathing difficulty, unusual bleeding or easy bruising, hives or acute pharyngitis are not common for patients under Cefepimum therapy. If such symptoms occur at any point of your treatment, call your doctor.

Since the FDA itself has doubts regarding Cefepimum's safety, it would be best to ask for an alternative medication you could use for your condition. If your doctor insists on Cefepimum, make sure that you are monitored closely to be safe.

Cefepimum has the following structural formula:

Chemical structure of cefepimum

• Molecular formula of cefepimum is C19H24N6O5S2
• Chemical IUPAC Name is (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]- 3-[(1-methylpyrrolidin-1-ium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• Molecular weight is 480.5611 g/mol
Cefepimum available : 100mg tablets

Generic name: Cefepime

Brand name(s): Axepim, Cefepima, Cepimax, Cepimex, Maxcef, Maxipime

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