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Chlorambucil

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Chlorambucil

Chlorambucil review





Chlorambucil is a powerful chemotherapy drug that is commonly used in treating chronic lymphocytic leukemia. Chlorambucil was formerly used against some types of non-Hodgkin lymphoma, ovarian carcinoma, and others. It was also used as an immunosuppressive drug for a number of inflammatory and autoimmune conditions, including nephrotic syndrome. Nowadays, it is mainly used in cases of chronic lymphocytic leukemia,

Chlorambucil is sold by GlaxoSmithKline under the brand name Leukeran. It is prescribed for people suffering from Hodgkin's disease, chronic lymphocytic leukemia, and Waldenstrom's macroglobulinaemia, among others.

There is a varying dosage for each type of condition. For example, for Waldenstrom's macroglobulinaemia, the initial requirement is 6-12 mg per day until leucopenia develops. Afterwards, the maintenance needed is 2-8 mg per day. Since Chlorambucil comes in 2 mg per brown tablet, the maintenance can range from one to four tablets per day.

Chlorambucil, however, should be taken with proper consultation with the doctors. This is also best taken on an empty stomach with lots of water. Make sure also that you don’t chew or crush the tablet.

In case you forget your dosage, do not take a double dosage on your next schedule. Inform your doctor and just continue with your usual dosage. Another case is if you vomit right after taking Chlorambucil, seek your doctor’s advice whether to take another or not.

If you are under this medication, bruising or bleeding is normal occurrence. Since the blood would lose platelet production, the ability of the blood to clot is affected. It is necessary to contact your doctor if you experience bleeding gums or blood spots.

Another major side effect is anemia. When you have anemia, you would feel tired more often. You would also feel as if you are always breathless. At the same time, nausea and vomiting may also be experienced. These can be controlled or lessened by some anti-emetic drugs.

There would also be lowered resistance level. Because of this, you may be prone to illnesses like colds. While taking Chlorambucil, you may also lose your appetite; however, there are still some tips that your doctors and dieticians can give you so that you can maintain a good weight.

On very rare cases, some people taking Chlorambucil develop mouth sore and ulcers, diarrhea, seizures, or fits, while some also report changes in food taste. There may also be effects on the liver, which are reversible after treatment.

There are also some fertility issues with regards to taking Chlorambucil. That is why it is advised to discuss contraception before considering medication.

Patients who are currently taking azidamfenicol are cautioned to take Chlorambucil. A combination of these drugs would result to additive toxicity. This is fatal and causes permanent damage.

There might be additional medications prescribed alongside Chlorambucil to prevent or lessen the side effects. These may include anti-emetic drugs and anti-diarrhea drugs. In such cases, keep in mind that you should inform your doctors right away of any reaction of the drugs. Doctors may change prescribed medications.

Chlorambucil is mutagenic: it can cause mutations in a person’s DNA. Pregnant women should also be aware that there are reports that fetus may be affected by it. To be safe, pregnant women are also advised to seek medical assistance on whether to breastfeed or not.

Chlorambucil has the following structural formula:

Chemical structure of chlorambucil


• Molecular formula of chlorambucil is C14H19Cl2NO2
• Chemical IUPAC Name is 4-[4-[bis(2-chloroethyl)amino]phenyl]butanoic acid
• Molecular weight is 304.212 g/mol
Chlorambucil available : 2mg tablets

Brand name(s): Ambochlorin, Amboclorin, Chlocambucil, Chloraminophen, Chloraminophene, Chlorbutin, Chlorbutine, Chloroambucil, Chlorobutin, Chlorobutine, Ecloril, Elcoril, Leukeran, Leukersan, Leukoran, Linfolizin, Linfolysin, Pepstatin

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