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Chloraminophene

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Chloraminophene

Chloraminophene review





Chloraminophene is a powerful chemotherapy medication used in treating chronic lymphocytic leukemia. Chloraminophene was used against some types of non-Hodgkin lymphoma and ovarian carcinoma and as an immunosuppressive medication for inflammatory and autoimmune conditions, including nephrotic syndrome. Now, it is mainly used in cases of chronic lymphocytic leukemia.

Chloraminophene is distributed by GlaxoSmithKline under the brand name Leukeran. It is for people suffering from Hodgkin's disease, chronic lymphocytic leukemia, and Waldenstrom's macroglobulinaemia, among others.

There is a varying dosage for each condition. For example, for Waldenstrom's macroglobulinaemia, the initial dose is 6-12 mg per day until leucopenia develops. After, the maintenance dose is 2-8 mg per day. Since Chloraminophene comes in a 2 mg brown pill, the maintenance can range from one to four pills per day.

Chloraminophene should be taken with proper supervision of a doctor. It is also best taken on an empty stomach with lots of water. Make sure that you do not chew or crush the pill.

If you miss a dosage, do not take a double dose at your next scheduled dosage. Inform your doctor of the missed dose and continue with your usual dosage. If you vomit right after taking Chloraminophene, seek your doctor's advice whether to take another or not.

If you are taking this medication, bruising or bleeding is normal. Since the blood will lose platelet production, the ability of the blood to clot is affected. Contact your doctor if you experience bleeding gums or blood spots.

Another side effect is anemia. When you have anemia, you feel tired often. You also feel as if you are breathless. At the same time, nausea and emesis may be experienced. These side effects can be controlled or lessened by some anti-emetic medications.

Some patients will experience a lowered resistance level. Due to this, they may be prone to diseases like colds. While taking Chloraminophene, you may lose your appetite. There are still some tips that your doctor or dietician can give you so you can maintain a healthy weight.

In rare cases, some people taking Chloraminophene develop mouth sores, ulcers, diarrhea, seizures, or fits, while some also report changes in food taste. There may also be effects on the liver that are reversible after treatment.

There are some fertility issues when taking Chloraminophene. That is why it is advised to discuss contraception with your doctor before taking this medication.

Patients taking azidamfenicol are cautioned against taking Chloraminophene. A combination of these medications may result in additive toxicity, which can be fatal or cause permanent damage.

There might be medications prescribed alongside Chloraminophene to prevent or lessen the possible side effects. These include anti-emetic medications and anti-diarrhea medications. Keep in mind that you should inform your doctor right away of any reaction of the medications. Doctors may change your prescribed medications based on your response to the treatment.

Chloraminophene is mutagenic, meaning that it can cause mutations in a person's DNA. Pregnant women should be aware that there are reports that fetus may be affected by Chloraminophene. To be safe, pregnant women are advised to talk with their doctor regarding whether to breastfeed or not.

Chloraminophene has the following structural formula:

Chemical structure of chloraminophene


• Molecular formula of chloraminophene is C14H19Cl2NO2
• Chemical IUPAC Name is 4-[4-[bis(2-chloroethyl)amino]phenyl]butanoic acid
• Molecular weight is 304.212 g/mol
Chloraminophene available : 2mg tablets

Generic name: Chlorambucil

Brand name(s): Ambochlorin, Amboclorin, Chlocambucil, Chloraminophen, Chlorbutin, Chlorbutine, Chloroambucil, Chlorobutin, Chlorobutine, Ecloril, Elcoril, Leukeran, Leukersan, Leukoran, Linfolizin, Linfolysin, Pepstatin

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