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Chloramphenicol

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Chloramphenicol

Chloramphenicol review





Chloramphenicol is a synthetic antibiotic that was first introduced to the medical world in 1949. Since its inception, it has been found useful as a treatment for bacterial infections caused by drug-resistant microorganisms. It has been widely used in many third-world countries because it is considerably cheap when compared to other antibiotics. In the United States, however, Chloramphenicol is used rarely due to its suspected role in the patient’s increased risk for aplastic anemia. The only popular forms of Chloramphenicol in the West are ointment and eye drops, which are used to reduce the symptoms of bacterial conjunctivitis. In other countries, Chloramphenicol is found to be useful in treating pneumonia and other bacterial infections that involve the eye and the prostrate gland.

Chloramphenicol is administered by mouth, through an IV, and topically. Oral Chloramphenicol comes in 250mg capsules and 125mg/5ml liquid suspension while other forms come in a variety of dosages. The usual dosage is 50mg per kilogram of body weight distributed evenly in four dosing schedules. Severe conditions require double dosage while newborns use only half since they do not metabolize the drug as effectively.

Special precautions must be well taken cared of before the administration of Chloramphenicol. Young children, four years and below, who are using this treatment must be closely monitored. Chloramphenicol may induce abnormal activity of blood cells, which may cause serious health effects. Since it is metabolized by the liver, any form of liver disorder should be of utmost concern. People with liver and kidney diseases must receive a dosage adjustment from their doctors to avoid any more damage. Pregnant and lactating women should never take Chloramphenicol without the advice of their doctor. Like some other medicines, Chloramphenicol may pose harm to the fragile bodies of fetuses and newborns alike.

If you are using other drugs for different conditions, inform your doctor about each one of them, including your vitamins. Some medicines react violently to Chloramphenicol and must not be taken alongside it.

The reason Chloramphenicol did not boom in the US is its harsh side effects. The most severe of which is aplastic anemia, a condition that is very rare yet scary because it can have fatal effects. It is not yet proven that blood count monitoring can prevent aplastic anemia from occurring but it has been widely observed to shake off any possibilities of complications connected with a Chloramphenicol treatment. The higher risk for aplastic anemia is found on patients who are using it orally; the least risky is the eye drops form. Other possible side effects of Chloramphenicol include bone marrow suppression, childhood leukaemia, and Gray Baby Syndrome among others.

To be safe while taking Chloramphenicol, make sure that you are closely monitored by a health professional. Keeping a close watch on the progress of your symptoms and on the responses of your body to the medication will help your doctor resolve a problem early. Never take the medicine without your doctor’s advice and never use another person’s or an old prescription to your current condition.

Chloramphenicol has the following structural formula:

Chemical structure of chloramphenicol


• Molecular formula of chloramphenicol is C11H12Cl2N2O5
• Chemical IUPAC Name is 2,2-dichloro-N-[1,3-dihydroxy-1-(4-nitrophenyl)-propan-2-yl]-acetamide
• Molecular weight is 323.129 g/mol
Chloramphenicol available : 250mg tablets

Brand name(s): Alficetyn, Ambofen, Amphenicol, Amphicol, Amseclor, Anacetin, Aquamycetin, Austracil, Austracol, Biocetin, Biophenicol, Catilan, Chemicetin, Chemicetina, Chlomin, Chlomycol, Chlora-Tabs, Chloramex, Chloramfenikol, Chloramficin, Chloramfilin, Chloramphenicole, Chloramsaar, Chlorasol, Chloricol, Chlornitromycin, Chlorocaps, Chlorocid, Chlorocide, Chlorocol, Chlorofair, Chloromax, Chloromycetin, Chloromycetny, Chloromyxin, Chloronitrin, Chloroptic, Chlorovules, Cidocetine, Ciplamycetin, Cloramfen, Cloramficin, Cloramicol, Cloramidina, Cloroamfenicolo, Clorocyn, Cloromisan, Clorosintex, Comycetin, Cylphenicol, Desphen, Detreomycin, Detreomycine, Dextromycetin, Doctamicina, Econochlor, Embacetin, Emetren, Enicol, Enteromycetin, Erbaplast, Ertilen, Farmicetina, Farmitcetina, Fenicol, Globenicol, Glorous, Halomycetin, Hortfenicol, Intramycetin, Isicetin, Ismicetina, Isophenicol, Juvamycetin, Kamaver, Kemicetina, Kemicetine, Klorita, Leukamycin, Leukomyan, Leukomycin, Levomicetina, Levomitsetin, Levomycetin, Liquichlor, Loromisan, Loromisin, Mastiphen, Mediamycetine, Medichol, Micloretin, Micochlorine, Micoclorina, Microcetina, Mychel, Mycinol, Normimycin V, Novochlorocap, Novomycetin, Novophenicol, Oftalent, Oleomycetin, Opclor, Opelor, Ophthochlor, Ophthoclor, Ophthocort, Ophtochlor, Optomycin, Otachron, Otophen, Owadziak, Pantovernil, Paraxin, Pedraczak, Pentamycetin, Pflanzol, Quellada, Quemicetina, Rivomycin, Romphenil, Ronphenil, Septicol, Sificetina, Sintomicetina, Sno-Phenicol, Stanomycetin, Synthomycetin, Synthomycetine, Synthomycine, Tevcocin, Tevcosin, Tifomycin, Tifomycine, Tiromycetin, Treomicetina, Tyfomycine, Unimycetin, Veticol, Viceton

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