Chlorazepate review

Chlorazepate is a benzodiazepine medication that contains anxiolytic, sedative, and anticonvulsant properties. It affects the chemicals in one's brains which, when imbalanced, can result in seizures or anxiety.

Chlorazepate is recommended for persons who need relief from anxiety, seizures, and agitation resulting from alcohol withdrawal. It can also be used to cure irritable bowel syndrome. It is available under the brand names Novo-Clopate and Tranxene.

Chlorazepate comes in tablet form and is taken orally. It can be taken up to four times a day, with a minimum dose of 15 milligrams and maximum of 60 milligrams. It can be administered on an empty stomach.

The medication will begin to act on the body a couple of hours after intake. The effects can be felt for one day, and even longer in some cases.

Since Chlorazepate is habit-forming, users are advised not to take larger doses or use it for a longer time than prescribed by a physician. Users may also develop tolerance with the medication if it is excessively used, resulting in the medication becoming less effective.

Patients should not skip doses even if they feel better. They should follow the regular dosing schedule as prescribed by a physician. Patients should not take Chlorazepate for longer than 4 months without consulting a physician. Likewise, suddenly stopping use of the medication can worsen the patient's condition and result in various withdrawal symptoms like irritability, anxiety attacks, and sleeplessness.

Patients should never take a double dose in order to make up for a missed dose. In case of a missed dose, simply take it as soon as the patient remembers it. If the next dose is almost due, simply skip the missed dose and take Chlorazepate as scheduled.

Users of Chlorazepate may also experience side effects, although the chances are quite low. Some of the common side effects may include drowsiness, tiredness, dizziness, xerostomia, weakness, upset stomach, diarrhea, and changes in mood and appetite.

Some of the more serious side effects include restlessness, difficulty in or frequent urination, costiveness, blurred vision, changes in libido, seizures, fever, shuffling walk, persistent tremor, rashes, irregular heartbeat, and difficulty In swallowing or breathing.

Before taking Chlorazepate, patients should inform their doctors of any allergy to any of these medications: alprazolam, clonazepam, chlodiazepoxide, flurazepam, prazepam, oxazepam, temazepam, and triazolam. These medications can interact negatively with Chlorazepate.

Non prescription and prescription medications such as antihistamines, digoxin, cimetidine, disulfiram, isoniazid, fluoxetine, levodopa, ketoconazole can also affect the effectiveness of Chlorazepate.

Chlorazepate can also have its effects lessened when taken along with medications for seizures, depression, pain, Parkinson's disease, asthma, and allergies, as well as medications such as muscle relaxants, probenecid, oral contraceptives, rifampin, sedatives, and sleeping pills.

Patients should also inform their doctors of their medical history especially if they have had seizures, glaucoma, lung, liver, and heart diseases. Meanwhile, women who are pregnant or are planning to conceive should also notify their physicians before agreeing to take Chlorazepate.

Chlorazepate has the following structural formula:

Chemical structure of chlorazepate

 Molecular formula of chlorazepate is C16H11ClN2O3
 Chemical IUPAC Name is 7-chloro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepine-3-carboxylic acid
 Molecular weight is 314.7231 g/mol
 Chlorazepate available : 20mg tablets

Generic name: Clorazepate

Brand name(s): Chlorazepic Acid, Clorazepic acid, Gen-xene, Tranxene, Tranxilium

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