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Chlorbutine

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Chlorbutine

Chlorbutine review





Chlorbutine is a powerful chemotherapy medicament used in treating chronic lymphocytic leukemia. Chlorbutine was used against some types of non-Hodgkin lymphoma and ovarian carcinoma and as an immunosuppressive medicament for inflammatory and autoimmune conditions, including nephrotic syndrome. Now, it is mainly used in cases of chronic lymphocytic leukemia.

Chlorbutine is distributed by GlaxoSmithKline under the brand name Leukeran. It is for patients with Hodgkin's disease, chronic lymphocytic leukemia, and Waldenstrom's macroglobulinaemia, among others.

There is a varying dosage for each condition. For example, for Waldenstrom's macroglobulinaemia, the initial dose is 6-12 mg per day until leucopenia develops. After, the maintenance dose is 2-8 mg per day. Since Chlorbutine comes in a 2 mg brown tablet, the maintenance can range from one to four tablets per day.

Chlorbutine should be taken with proper supervision of a physician. It is also best taken on an empty stomach with lots of water. Make sure that you do not chew or crush the tablet.

If you miss a dosage, do not take a double dose at your next scheduled dosage. Inform your physician of the missed dose and continue with your usual dosage. If you vomit right after taking Chlorbutine, seek your physician's advice whether to take another or not.

If you are taking this medicament, bruising or bleeding is normal. Since the blood will lose platelet production, the ability of the blood to clot is affected. Contact your physician if you experience bleeding gums or blood spots.

Another side effect is anemia. When you have anemia, you feel tired often. You also feel as if you are breathless. At the same time, nausea and emesis may be experienced. These side effects can be controlled or lessened by some anti-emetic medicaments.

Some patients will experience a lowered resistance level. Due to this, they may be prone to diseasees like colds. While taking Chlorbutine, you may lose your appetite. There are some tips that your physician or dietician can give you to maintain a healthy weight.

In rare cases, some patients taking Chlorbutine develop mouth sores, ulcers, diarrhea, seizures, or fits, while some also report changes in food taste. There may be effects on the liver that are reversible after treatment.

There are some fertility issues when taking Chlorbutine. Discuss contraception with your physician before taking this medicament.

Patients taking azidamfenicol are cautioned against taking Chlorbutine. The combination of these medicaments may result in additive toxicity, which can be fatal or cause permanent damage.

There may medicaments prescribed alongside Chlorbutine to prevent or lessen the possible side effects. These include anti-emetic medicaments and anti-diarrhea medicaments. Inform your physician right away of any reaction of the medicaments. Physicians may change your prescribed medicaments based on your response to the treatment.

Chlorbutine is mutagenic, meaning that it can cause mutations in a patient's DNA. Pregnant women should be aware that there are reports that fetus may be affected by Chlorbutine. To be safe, pregnant women are advised to talk with their physician regarding this medicament before taking it.

Chlorbutine has the following structural formula:

Chemical structure of chlorbutine


• Molecular formula of chlorbutine is C14H19Cl2NO2
• Chemical IUPAC Name is 4-[4-[bis(2-chloroethyl)amino]phenyl]butanoic acid
• Molecular weight is 304.212 g/mol
Chlorbutine available : 2mg tablets

Generic name: Chlorambucil

Brand name(s): Ambochlorin, Amboclorin, Chlocambucil, Chloraminophen, Chloraminophene, Chlorbutin, Chloroambucil, Chlorobutin, Chlorobutine, Ecloril, Elcoril, Leukeran, Leukersan, Leukoran, Linfolizin, Linfolysin, Pepstatin

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