Chlorimipramine review

Ever wondered why there are people who are obsessive and are now popularly known to have an obsessive-compulsive disorder (OCD)? Wonder if there is a cure? Let Chlorimipramine help you with this.

This is a frequently prescribed medication for OCD treatment but has more side effects than the SSRI's which prevent serotonin from being reabsorbed by the cell and consequently helps prolong that light feeling that the brain needs. This function is acknowledged to relieve depression and anxiety.

Defined as the 3-chloro derivative of imipramine, it is seriously potent but not exactly an SSRI because the primary active metabolite desmethylclomipramine acts as a norepinephrine reuptake inhibitor.

Aside from the said indications, it is also used for panic attacks with or without agoraphobia, narcolepsy, premature ejaculation, chronic pain and enuresis. Similar to other SSRI's, it also takes 2- 3 weeks for the patient to experience the full benefits of the medication.

Though said to have more side effects that SSRI's, it is considered a second-line treatment should your SSRI fail. It might even be slightly more effective as far as treating the symptoms of OCD are concerned. Curiously enough, Chlorimipramine and SSRI's (Paroxetine) are considered potent treatments for premature ejaculation.

One of the downsides of the medication is that it has a higher incident of seizures than other tricyclic anti-depressants. But even if this is the case, it is touted to be slightly better in the treatment of depression as compared to other tricyclics.

As a non-controlled substance, there is a potential for its abuse or dependence. Withdrawal symptoms occur once you abruptly stop its use. Such symptoms include agitation, fatigue, nausea, cephalalgias, insomnia, sometimes activation of mania and rebound of depression or anxiety. If there is a need to immediately terminate its use, benzodiazepines should be taken up to four weeks (if needed) to suppress the unpleasant symptoms.

Like most medications with relative effects, there's also a list of side effects associated with the medication which includes fatigue, dizziness, lightheadedness, cephalalgias, confusion, agitation, insomnia, nightmares, increased anxiety, and seizures (0,5% to 2%, see above)

It also has anticholingeric side effects such as xerostomia, constipation, rarely ileus (paralysis of the large intestine, life-threatening), difficulty urinating, sweating, precipitation of glaucoma (may lead to permanent eye-damage or even blindness, if untreated).

Because of the strong central and peripheral blockage of alpha receptors, antiadrenergic side effects might also be experienced such as hypotension, postural collapse (when patient is rising too fast from lying or sitting position to standing), arrhythmias (sinus tachycardia, bradycardia, AV block, rarely other forms of cardiac problems). Preexisting heart insufficiency can be worsened.

Those suffering from emotional instability should receive the smallest amount of the medication. It is also advised to be cautious with its use on elderly people because they are more prone to the effects of the medication. Pregnant women should only use this medication if clearly needed because it is excreted into breast milk.

Chlorimipramine has the following structural formula:

Chemical structure of chlorimipramine

• Molecular formula of chlorimipramine is C19H23ClN2
Chlorimipramine available : 10mg tablets, 25mg tablets, 75mg tablets

Generic name: Clomipramine

Brand name(s): Anafranil, Clomipramina, Clomipraminum, Hydiphen

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