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Cisapride

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Cisapride

Cisapride review





People with gastrointestinal problems can now find relief with the development of cisapride. The effective actions of the medication have shown to be quite useful for many for years to come. It does have a number of reactions and effects that should also be watched out for.

Cisapride is the generic name of the gastrointestinal stimulant drug used for the treatment of nighttime heartburn, bowel constipation and GERD or gastroesophageal reflux disease. It is also known under its brand name Propulsid and Prepulsid. Patients who do not respond well to other forms of treatment and therapies are given Cisapride to improve their condition.

Cisapride comes in liquid form and tablets which should be taken orally. Although the drug has shown potency in treating bowel disorders, doctors are discouraged from immediately giving the drug unless other alternatives are rendered ineffective. It was approved by the FDA or Food and Drug Administration in 1993 but later on was withdrawn in several areas or had limited indications due after reports of arrhythmia and cardiac irregularities symptoms surfaced.

The gastrointestinal stimulant drug is also indicated in treating megaesophagus and feline megacolon. However, it should not be used for other alternative uses unknown to patients’ doctors. It is also useful for nausea stemming from motility problems. Cisapride is highly related to metoclopramide for their similar effects but the latter is more potent in treating neurologic reactions.

A number of side effects can also result from the drug which should be cautiously watched out for. Individuals should stop the drug immediately and report to the doctor if any of these are noticed: fainting, allergic reactions, cardiac arrhythmia, chest pain, difficulty breathing and vision changes. Less serious side effects include abdominal pain, diarrhea, constipation, nausea, urinary frequency, upset stomach, runny nose, cough and headache. Patients may resume taking Cisapride but the symptoms should still be reported. Cisapride overdose is also possible through manifestations like diarrhea, vomiting, flatulence, tremor, seizure, weakness and nausea.

Pregnant women and nursing mothers should consult their physician first before taking the drug. Females trying to conceive should not take the drug since it can reduce fertility. Cisapride may also interact with drugs like cimetidine, ranitidine, antifungals like ketoconazole, antihistamines, psychoactive drugs, heart medications and benzodiazepines. If there is actual intestinal perforation or obstruction, the drug is contraindicated. Pomegranate juice, tobacco, alcohol, grapefruit juice and red wine are also known to reduce the effects and absorption of the drug in the body. Other contraindications include patients with a history of heart and arterial disease.

Cisapride is a parasympathomimetic drug that acts as an agonist for serotonin 5-HT4 receptors. Once the receptors are stimulated, acetylcholine levels will rise in the enteric nervous system thereby improve gastroesophageal condition. The esophageal sphincter also improves plus effective gastric emptying.

A clinical trial involving 18 patients suffering from GERD were treated with cisapride and metoclopramide. The group was divided into two wherein the first batch was given cisapride while the second took metoclopramide. After 7 days, both batches exhibited improvement in gastroesophageal condition. The first batch did experience nausea for 1 to 2 days but the second batch reported experiencing moderate neurologic side effects.

Cisapride is a prescription medication and should only be bought from authorized clinics and pharmacies. Be sure to verify any online pharmacy before purchasing to guarantee authenticity of products.

Cisapride can be given up to three times daily. Never take more than the recommended dosage. The drug should be stored at room temperature free from heat, moisture and children’s reach. Watch out for symptoms of overdose and immediately call for help if anything results. Doctors require laboratory assessment to ensure safety of patient toward the drug.

Cisapride has the following structural formula:

Chemical structure of cisapride


• Molecular formula of cisapride is C23H29ClFN3O4
• Chemical IUPAC Name is 4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin- 4-yl]-2-methoxybenzamide
• Molecular weight is 465.9455 g/mol
Cisapride available : 5mg tablets, 10mg tablets

Brand name(s): Acenalin, Alimix, Cipril, Enteropride, Kinestase, Prepulsid, Pridesia, Propulsid, Propulsin, Risamal, Syspride

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