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Citalopram

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Citalopram

Citalopram review





As the original form of Citalopram, it is considered as one of the most effective anti depressants ever produced. Created in 1989, it paved the way for other companies to produce the generic versions upon the expiration of its patent in 2003. One of them is the known as Cipralex or Lexapro with Forest Laboratories as the manufacturers of the drug who acquired the license rights from Forest Lundbeck. They are manufactured in Denmark.

Formulated to treat the symptoms of depression, it was also the preferred medicine for prescription to cure prescribed for a lot of other illnesses such as social anxiety disorder panic disorder or obsessive-compulsive disorder. Also prescribed in Huntington's disease and premenstrual dysphoric disorder.

It's also being used for other use that are yet to be officially approved. They include the significant reduction of symptoms of diabetic neuropathy and premature ejaculation. Some also claim with evidence that Citalopram might be effective for the treatment of post-stroke pathological crying. Taken alone, it is slightly effective treatment than amitriptyline for the prevention of migraines, in refractory cases combination therapy may be more effective.

Though Citalopram is considered to be generally safe and well tolerated with a dose range of 20 to 60 mg a day, constant monitoring of the doctor of the patien taking it is required. Pretty distinct from the others of its class, it exhibits linear pharmacokinetics and minimal drug interaction potential. This makes it the better choice for the elderly or comorbid patients. However, Citalopram should always be taken with caution.

The drug has a number of adverse effects. According to a study with clinical trials, it was reported that over 10% of patients reported displayed adverse reactions such as fatigue, drowsiness, dry mouth, increased sweating (hyperhidrosis), trembling, headache, dizziness, sleep disturbances, insomnia, cardiac arrhythmia, blood pressure changes, nausea and/or vomiting, diarrhea, heightened anorgasmia in females, impotence and ejaculatory problems in males.

There were even rare cases (around over 1% of cases), which displayed allergic reactions, convulsions, mood changes, anxiety and confusion.

Another side effect is sedation that may be may be present while under treatment from citalopram. Should this happen, it is advisable to take the dose at bedtime instead of in the morning.

A unique side effect is bruxism (teeth grinding). Upon starting the treatment, patients would also experience a feeling similar to electricity or minor shocks in their upper body and in their hands. It was concluded that the chemical changes occurring in the brain which pass with time is the cause of this. On seperate occasions, there might also be panic attacks, thoughts of suicide or self-injury which might increase in the first few weeks, before the antidepressant effect starts.

As far as sexual side effects are concerned, it was also reported to affect both males and females. Usually reversible, it can last for months or years even after the drug has been completely withdrawn with the disorder known as Post SSRI Sexual Dysfunction.

Citalopram has the following structural formula:

Chemical structure of citalopram


• Molecular formula of citalopram is C20H21FN2O
• Chemical IUPAC Name is 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
• Molecular weight is 324.392 g/mol
Citalopram available : 60mg tablets

Brand name(s): Celexa, Cipram, Cipramil, Citalopramum, Nitalapram

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