Claphene review

Claphene is a medication used to treat various types of cancer. Aside from being a cytotoxic medication, Claphene is an immunosuppressive (it suppresses the immune system).

Claphene is marketed under the brand name Cytoxan and is available in tablet form or a powder used for intravenous injection. It is prescribed to patients who are suffering from certain types of cancer such as ovarian, breast, and leukemia. It is also known to cure nephritic syndrome, an ailment of the kidneys among children.


The initial dose of Claphene is at least 40 mg injected in a stretch of 3 to 5 days divided in various doses. The standard dosage for oral use is 1 to 5 mg/kg per day. The dose is then adjusted based on the tumor's response to the medication and its side effects.

Claphene should be taken as prescribed by your doc. While taking Claphene, patients should drink more water and urinate more frequently. This should help the kidneys to remove the medication from the system and lower the chances of occurrence of side effects.

Patients should not stop using Claphene until the prescribed schedule is complete, even if the patient experiences nausea or vomiting.

This medication usually works a month or two before producing positive results. The effects also depend on the illness being treated.


One of the most common side effects is nausea. Doctors usually prescribe another medication to reduce this side effect.

Users may also experience bleeding and inflammation of the bladder wall, or haemorrhagic cystitis characterized by blood in the urine. To reduce the chances of this side effect, patients are advised to drink more water, preferably up to 10 glasses a day.

This medication can also have an effect on the blood count of the patient. It can also result in baldness, irregular menstrual periods, and mouth ulcers. In case a patient develops these symptoms after using Claphene, he or she should immediately inform their doc.

Patients who come into close contact with a person with chicken pox are advised to stop using Claphene and immediately consult their doc. This case usually requires a special, antiviral intervention since chicken pox can be severe among people who are undergoing intervention with Claphene.

Since Claphene may affect the bladder and the blood, docs may have to arrange for a blood and urine examination before allowing the patient to start intervention with Claphene. Regular examinations are also required while the patient takes Claphene. Patients should not take Claphene unless they are undergoing regular blood and urine examinations.


Certain medicaments may interact negatively with other medicaments. Patients should make it a point to inform their physicians if they are beginning to take new medicaments while taking Claphene.

Taking Claphene may lead to a decrease in fertility among women and men; so young users are advised to use this medication with caution.


Pregnant women should never take this medication. Claphene may also be passed on to infants so breastfeeding mothers should not take this medication.

Claphene has the following structural formula:

Chemical structure of claphene

 Molecular formula of claphene is C7H15C12N2O2P·H2O
 Chemical IUPAC Name is 2-[bis(2-chloroethyl)amino] tetrahydro-2H-13,2-oxazaphosphorine 2-oxide monohydrate
 Molecular weight is 279.1 g/mol
 Claphene available : 25mg tablets, 50mg tablets

Generic name: Cyclophosphamide

Brand name(s): Clafen, Cyclophosphamid, Cyclophosphamidum, Cyclophosphan, Cyclophosphane, Cyclophosphoramide, Cyclostin, Cyklofosfamid, Cytophosphan, Cytoxan, Endoxan, Endoxan R, Endoxana, Endoxanal, Endoxane, Enduxan, Genoxal, Hexadrin, Lyophilized Cytoxan, Mitoxan, Neosar, Procytox, Semdoxan, Sendoxan, Senduxan, Zyklophosphamid

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