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Clavulanate

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Clavulanate

Clavulanate review





Clavulanate belongs to a group of antibiotics called penicillin. When combined with Amoxicillin, Clavulanate fights bacteria that cause various infections in the body.

Clavulanate is available under the brand name Augmentin which comes in tablet and liquid forms. It should be taken by persons who are undergoing treatment for various infections such as sinusitis, urinary tract infections, pneumonia, bronchitis, ear infections, and skin infections. It can be taken by adults and even children. Clavulanate, however, is not effective in treating common infections like flu or colds.

Adults are usually prescribed to take 500 milligrams of Clavulanate every 12 hours, or 250 milligrams every 8 hours. For more severe cases of infections particularly in the respiratory tract, the dosage can be increased to 875 milligrams every 12 hours, or 500 milligrams every 8 hours.

Those who have weakened renal function are not required to have a reduction in dosage unless their injury is serious. Usually, seriously injured patients are not allowed to take 875 milligrams of Clavulanate.

Patients suffering from hemodialysis are required to have at least 250 milligrams of Clavulanate depending on the seriousness of the infection. Patients are required to take additional dosage during and after dialysis. Children who weigh more than 80 lbs should be given dosage similar to those of adults.

Cluvalanate can be administered even if the patient has an empty stomach. However, for best results it is advised that the patient take Cluvalanate prior to taking a meal. It would also lessen the chances of a gastrointestinal problem.

The tablet form of Augmentin should be taken as a whole. The chewable tablet should be chewed before ingesting, and never swallowed as a whole. The extended-release type of tablet should be swallowed completely, or broken into halves. The liquid form should be shaken first before taking.

Clavulanate must be taken at equal intervals as prescribed by a physician or pharmacist. Taking the drug regularly allows a patient to get the most out of the effectiveness of Clavulanate.

In case a patient misses a dose, he or she should take it immediately. If the next dose is almost up, it is recommended that he or she pass over the missed dosage and then proceed to take the dosage at the next scheduled dosage. It is not recommended that patients take another medicine to make up for a missed dose.

Like most medicines, Clavulanate can result to side effects, although the chances are pretty low. Some of the less serious side effects include difficulty in breathing, hives, and swelling of the face, lips, and throat. More serious side effects may include fever, stomach pain, lack of appetite, and yellowing of the eyes or skin.

Patients should consult a doctor immediately in case any of these side effects become apparent or persist.

Clavulanate, like most antibiotic medicines, can cause a patient to have diarrhea which could indicate a new infection. Patients should immediately notify a doctor especially if their bowel has watery or blood in it. Never use a drug to control the diarrhea unless prescribed by a physician.

Patients who have kidney or liver disease should inform their physician about their condition prior to taking Clavulanate. These conditions can prevent a patient from taking Clavulanate, or can require adjustment in the dosage.

Clavulanate has the following structural formula:

Chemical structure of clavulanate


• Molecular formula of clavulanate is C8H9NO5
• Chemical IUPAC Name is (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa- 1-azabicyclo[3.2.0]heptane-2-carboxylicacid
• Molecular weight is 199.1608 g/mol
Clavulanate available : 250mg tablets, 500mg tablets, 625mg tablets, 875mg tablets

Brand name(s): Amoksiklav, Augmentin, Ciblor, Clavulanic acid, Klavocin, Neo-Duplamox

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