is a beta-lactamase inhibitor drug, which strengthens the effect of antibiotic against infection. It is a prescription medicine used in combination with Amoxicillin
under the trade name Augmentin
. Augmentin is commonly prescribed to patients who have strong resistance to antibiotic due to the presence of beta-lactamase enzymes.
Clavulanic Acid is used by patients with ear
, throat, lung
, and skin infections. It is also effective in treating several types of sexually transmitted diseases. The presence of Clavulanic Acid in Amoxicillin enhances its strength in dealing with the bacteria.
The usual dosage of Clavulanic Acid is 125mg per tablet, 28.5mg to 62.5mg per chewable tablet, and 28.5mg to 62.5 per 5ml liquid suspension. Excessive intake of Clavulanic Acid can cause an upset stomach
so it is best that you ask advice from your doctor regarding the suitable amount to be used in your case.
Before taking Amoxicillin with Clavulanic Acid, you must first make a consultation with your doctor regarding the special precautions. You need to discuss your allergic tendencies, medical history, and a summary of prescription and non-prescription medicines that you are currently taking. Pregnant and nursing women are special cases to be given special attention. Some medicines may cause fetal harm or may excrete in the breast
milk and affect the newborn. It is advisable that you first ask your doctor if you are safe with Clavulanic Acid or not.
Since Clavulanic Acid may sometimes upset the stomach, it should be taken with food or milk unless the doctor tells you otherwise. Abdominal disturbance is the most common side effect of taking this drug. Heartburn
, and vomiting
are also typical. If those cases persist or worsen, you must call your doctor immediately. Other alarm signs include major and uncommon side effects such as easy bruising or bleeding, jaundice, swelling
, vaginal infection, and skin rash.
Clavulanic Acid and Amoxicillin preparations have been associated in increased risk for hepatitis, especially in men aged 65 years old and above. Allergic reactions
that are sometimes fatal have also been recorded. Interactions of Clavulanic Acid against other drugs may also cause serious physical discomfort. That is why Clavulanic Acid intake must be closely monitored by a health professional. Normally, it must not be taken for more than 14 days.
Clavulanic Acid can make birth control
pills become ineffective. It is quite dangerous for a woman to become pregnant while under medication thus, it would be best to ask for advice regarding an alternative birth control method you could use while you are undergoing the treatment.
Do not use or overuse Clavulanic Acid at any point. Stay within the prescription period. If you feel that you must stop taking the drug earlier or prolong its use, consult your doctor. Only the doctor knows whether you need a dosage adjustment or not. If you stop using Clavulanic Acid before the prescription period is through, you may increase the risk of a relapse. If you prolong its use because your symptoms persist, you may damage the important organs of your body like your liver
and your kidney
Clavulanic acid has the following structural formula:
• Molecular formula of clavulanic acid is C8H9NO5
• Chemical IUPAC Name is (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylicacid
• Molecular weight is 199.1608 g/mol
• Clavulanic acid available : 250mg tablets, 500mg tablets, 625mg tablets, 875mg tablets