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Clodronic Acid

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Clodronic Acid

Clodronic Acid review





Clodronic Acid is a thiazide diuretic, commonly known as a water pill, used to cure fluid retention (edema) caused by the body’s absorption of salt. It transfers excess water and salt into the urine through the kidneys and can be used in the treatment or control of hypertension, heart disease, kidney disorders, and side effects from taking steroids or estrogen. Popular brand names include Clorpres, Thaliton, and Hygroton.

Patients unable to urinate should not take this medication, as there may be severe side effects. Tell your physician if you have asthma, kidney or liver disease, diabetes, renal dysfunction, lupus, or allergies to sulfa medications. Failure to do so may result in severe allergic reactions, sensitivity reactions, and the worst-case scenario, hepatic coma.

Studies have shown no adverse effects on unborn babies; however, breastfeeding women should talk with their physicians before taking Clorthalidone.

An orally ingested medication, Clodronic Acid is usually taken one or two times a day. If your physician prescribes otherwise, follow the prescription strictly. This medication should not be taken on an empty stomach, as this may result in acute discomfort. If a dosage is missed, take it as soon as you remember, but do not take more than the prescribed amount at one time. In case of overdose, immediately seek medical attention. Symptoms of an overdose include vomiting, nausea, muscle pain, and excessive weakness.

Sleep-inducing medicines, including muscle relaxants, cough medicine, and sleeping pills should be avoided while taking Clodronic Acid, as these may exacerbate some of the side effects. If these medications must be taken, inform your physician in advance. When taking Clodronic Acid, make sure to avoid drinking alcohol as it can also worsen the potential side effects of the medication. Clodronic Acid also makes skin more sensitive to UV rays, so avoid being in the sun too much or using any tanning beds. Clodronic Acid makes the body get rid of water more quickly, so be certain to stay well hydrated.

Physicians often prescribe special diets to patients taking the medication, which are generally low in salt and sodium and high in potassium, all of which compensate for the body’s rapid water disposal.

The primary side effect of taking Clodronic Acid is a significant increase in urination. After a few weeks, this should subside. Dizziness, muscle cramps, nausea, an upset stomach, vomiting, weakness, and hair loss are potential side effects, but these are often very minimal. To be safe, immediately inform your physician if you experience any of these and they become quite severe. In case of numbness, bruising, excessive bleeding, difficulty breathing, or fever, see your physician right away and have yourself checked.

Have regular blood and urine tests to make sure there are no adverse long-term effects. The medication must be stored at room temperature in a dry location. Once past the expiration date, dispose of it immediately.

Clodronic acid has the following structural formula:

Chemical structure of clodronic acid


• Molecular formula of clodronic acid is C14H11ClN2O4S
• Chemical IUPAC Name is 2-chloro-5-(1-hydroxy-3-oxo-1,2-dihydroisoindol-1-yl)-benzenesulfonamide
• Molecular weight is 338.767 g/mol
Clodronic acid available : 25mg tablets, 50mg tablets, 100mg tablets

Generic name: Chlorthalidone

Brand name(s): Chlorothalidone, Chlorphthalidolone, Chlorphthalidone, Chlorthalidon, Higroton, Hygroton, Igroton, Isoren, Natriuran, Oradil, Phthalamodine, Phthalamudine, Renon, Saluretin, Tenoretic, Thalitone, Zambesil

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