Clomiphene review

Couples may finally have their wish of having babies with clomiphene. This wonder fertility drug has become very popular for its radically safe and useful actions. Like other drugs, it also has some contraindications and precautions to ensure effectiveness.

Clomiphene is the generic name of the fertility drug used by women in order to increase their chances of conceiving or getting pregnant. It is used in helping women ovulate properly during cycles. Men as well can benefit as the drug is also known to improve low sperm counts. Clomiphene is also called clomifene or known under brand names like Clomid, Milophene and Serophene.

Clomiphene is a selective estrogen receptor modulator or SERM that treats female and male infertility. Anovulation or inability to produce mature and viable egg cells can be helped significantly since the drug stimulates proper release of hormones for successful ovulation. Examples of a condition treated with Clomiphene would be polycystic ovary syndrome. The medication is available in tablet form which should be taken orally.

Like all drugs, clomiphene can cause a variety of side effects. Patients should seek medical consultation and help upon observation of the following symptoms: nausea, vomiting, abdominal pain, pelvic pain, bloating, shortness of breath, vision changes, difficulty sleeping, dizziness, lightheadedness, irritability, nervousness, headache, changes in menstrual cycle, easy fatigability and flushing. Examples of more common side effects are mild nausea, breast discomfort, hot flushes and mild pelvic discomfort. Symptoms of anaphylactic reaction include lip and facial swelling, difficulty breathing and hives. Clomiphene overdose is also possible through symptoms like nausea, vomiting, abdominal pain, blurred vision and flushing. On some rare occasions, OHSS or ovarian hyperstimulation syndrome may result.

Special precautions are given to patients who are pregnant, breastfeeding and have history of thyroid disorder, endocrine disorder, endometriosis, liver disease, uterine fibroids, ovarian cyst, ovarian enlargement, undiagnosed vaginal bleeding and other long-term underlying conditions. Clomiphene is known to cause birth defects and should never be taken by pregnant women. Special monitoring should be given to patients with known hypersensitivity reactions to the drug. Individuals should not drive or handle machinery until full effects of the medication are realized. People should inform their physician about any herbal and nutritional supplements they are currently taking to avoid adverse interactions.

The mode of action of the drug is to inhibit estrogen action on the gonadotrope cells in the anterior pituitary gland. When estrogen receptors cannot recycle, the body will falsely detect that estrogen levels are lower even if they are within normal bounds. The result would be the production of more gonadotropin-releasing hormones from the hypothalamus leading to the secretion of follicle-stimulating hormone or FSH from the pituitary gland. Ovulation will improve by the release of these hormones.

44 women ages 22 to 28 who could not successfully conceive were included in a test. 22 were given 50 mg of clomiphene once a day after meals for a duration of 6 weeks. The other 22 women were given a placebo for 6 weeks as well. At the end of the test, 10 women taking clomiphene successfully became pregnant wherein 2 conceived by the end of the third week. Only 2 of those in the placebo group successfully became pregnant. The drug is also known to increase the likelihood of women having multiple births.

Clomiphene is a prescription medication and should only be bought at certified pharmacies and drugstores under the recommendations of a licensed health professional. It is important to be very meticulous in choosing sources when buying over the internet. The online Web site should be certified and approved in distributing prescription drugs.

Women who are already pregnant should not take clomiphene since it cannot improve the chances of multiple births at such a late stage. Each dose should be followed as indicated by the doctor. Take each dose with a full glass of water. Store the medication in room temperature away from light, heat, moisture and children’s reach.

Clomiphene has the following structural formula:

Chemical structure of clomiphene

• Molecular formula of clomiphene is C26H28ClNO
• Chemical IUPAC Name is 2-[4-[(Z)-2-chloro-1,2-di(phenyl)ethenyl]phenoxy]-N,N-diethylethanamine
• Molecular weight is 405.9596 g/mol
Clomiphene available : 50mg tablets

Generic name: Clomifene

Brand name(s): Androxal, Clomid, Clomifen, Clomifert, Clomiphene B, Clomivid, Clomphid, Clostilbegyt, Dyneric, Genozym, Ikaclomin, Milophene, Omifin, Serophene

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