is benzodiazepine medication that contains anxiolytic, sedative, and anticonvulsant properties. It affects the chemicals in one’s brains which, when imbalanced, can result to seizures or anxiety
Clorazepate is recommended to persons who need relief from anxiety, seizures, and agitation resulting from alcohol withdrawal
. It can also be used to cure irritable bowel syndrome
. It is available under the brand names Novo-Clopate and Tranxene
Clorazapate comes in table form and is administered through the month. It can be taken up to four times a day, with a minimum dosage of 15 milligrams and maximum of 60 milligrams. It can be administered on an empty stomach
The drug will begin to act on the body a couple of hours after intake. The effects can be felt for one day, and even longer in some cases.
Since Clorazapate is habit-forming, users are advised not to take larger doses or use it for a longer time than prescribed by a physician. Users may also develop tolerance with the drug if it is excessively used, resulting to the drug becoming less effective.
Patients should not skip doses even if they feel better. They should follow the regular dosing schedule as prescribed by a physician. Patients should not take Clorazepate for no longer than 4 months without consulting a physician. Likewise, suddenly stopping use of the drug can worsen the patient’s condition and result to various withdrawal symptoms like irritability, anxiety attacks, and sleeplessness.
Patients should never take double dose in order to make for a missed dosage. In case of a missed dose, simply take it as soon as the patient remembers it. If the next dose is almost up, simply skip the missed dose and take Clorazepate as scheduled.
Users of Clorazepate may also experience side effects, although the chances are quite low. Some of the common side effects may include drowsiness, tiredness, dizziness
, dry mouth
, weakness, upset stomach, diarrhea
, and changes in mood and appetite.
Some of the more serious side effects include restlessness, difficulty in or frequent
, blurred vision, changes in libido, seizures, fever
, shuffling walk, persistent tremor, skin rashes, irregular heartbeat
, and difficulty In swallowing
Before taking Clorazepate, patients should inform their doctors allergy
to any of these drugs- alprazolam
, chlodiazepoxide, flurazepam
, prazepam, oxazepam, temazepam, and triazolam. These drugs can interact negatively with Clorazepete.
Non prescription and prescription medications such as antihistamines, digoxin
, disulfiram, isoniazid, fluoxetine
can also affect the effectiveness of Clorazepate.
Clorazepate can also have its effects lessened when taken along with drugs for seizures, depression
, pain, Parkinson’s disease
, and allergies
, as well as drugs such as muscle relaxants, probenecid, oral contraceptives, rifampin
, sedatives, and sleeping pills.
Patients should also inform their doctors of their medical history especially if they have had seizures, glaucoma
, and heart diseases
. Meanwhile, women who are pregnant or are planning to conceive should also notify their physicians before agreeing to take Clorazapete.
Clorazepate has the following structural formula:
• Molecular formula of clorazepate is C16H11ClN2O3
• Chemical IUPAC Name is 7-chloro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepine-3-carboxylic acid
• Molecular weight is 314.7231 g/mol
• Clorazepate available : 20mg tablets