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Cloxacillinum

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Cloxacillinum

Cloxacillinum review





Cloxacillinum is one effective antibiotic promising good results without the risk of serious side effects. Like other medications, there are interactions and affects to watch for to ensure that patients stay healthy and safe.

CLOXACILLINUM ACTION

Cloxacillinum is the generic name of the semisynthetic antibiotic belonging in the same class as penicillin. It is also available as the brand names Cloxapen, Orbenin and Tegopen. The medication is primarily used to fight staphylococci bacteria that produce beta-lactamase. It has weaker antibacterial actions compared to benzylpenicillin and is less potent, causing fewer toxic reactions.

Cloxacillinum is highly useful in the treatment of staphylococcus infections. It is available in pills and suspension. The medication is for the treatment of respiratory tract infection, urinary tract infection, bone and joint infection and skin infection. Even infections in the heart and lungs can be treated with Cloxacillinum. In very severe cases the medication may be administered intravenously.

CLOXACILLINUM SIDE EFFECTS

Many side effects are associated with Cloxacillinum such as wamble, vomiting, diarrhea, abdominal pain, white patches on the tongue, vaginal itching or discharge, black tongue and sore mouth. Serious side effects that require immediate medical attention include shortness of breath, difficulty breathing and facial or lip swelling from anaphylactic reactions, seizure, bruising, bleeding, water diarrhea, abdominal cramping, tingling or loss of sensation in the extremities, confusion coma and irritability. Cloxacillinum overdose symptoms include hallucination, encephalopathy, confusion, electrolyte imbalance and skin rash.

Patients with a history of kidney illness, gastrointestinal or stomach problems, infectious mononucleosis and heart illness should consult their doctor before taking this medication. Pregnant women and breastfeeding mothers need to be cautious when taking this medication. Diabetic patients may experience false positive results on their glucose urine tests while taking this medication. Cloxacillinum may interact with other substances so consume alcohol moderately and ask a physician before taking medications like erythromycin, tetracycline, birth control pills, allopurinol and methotrexate. Patients with known hypersensitivity reactions to this medication should not take it.

CLOXACILLINUM PRECAUTIONS

Cloxacillinum is absorbed then distributed to the kidneys, liver, bone, bile, pleural fluid, ascitic fluid and synovial fluid with some amounts into the CSF as well. 90% to 95% of the medication binds to plasma proteins. Its main action inhibits bacterial cell wall synthesis by binding to PBPs or penicillin-binding proteins. The result is the inhibition of transpeptidation phase of peptidoglycan synthesis in cell walls of bacteria, which prevents biosynthesis of cell walls. Bacteria is then engulfed, swallowed or destroyed as cell wall formation is disrupted.

CLOXACILLINUM DOSAGE

A clinical study was conducted involving 18 patients with skin infection caused by staphylococci. Half of the group was given 250 mg of Cloxacillinum every 6 hours for two weeks while the rest were provided with a placebo. After the first week, those on Cloxacillinum showed significant improvement in their skin and by the second week, 7 out of 9 were already showing signs of being free from infection like absence of moisture and pus. None of those on placebo showed any improvement while 3 even had exacerbated symptoms like pyrexia.

Cloxacillinum is an over-the-counter or OTC medication, which can easily be bought at any pharmacy, clinic or online drug store. Check the expiration date, manufacturer and address to ensure that products are legitimate and authentic. When buying online, make sure that the source is certified.

Cloxacillinum should not be abruptly stopped even if individuals already feel better. Each dose should be taken with a full glass of water on an empty stomach around 1 hour before or 2 hours after meals. Avoid drinking juice or carbonated drinks with the medication since these can reduce effectiveness.

Cloxacillinum has the following structural formula:

Chemical structure of cloxacillinum


 Molecular formula of cloxacillinum is C19H18ClN3O5S
 Chemical IUPAC Name is 7-[[3-(2-chlorophenyl)-5-methyl-oxazol-4-yl]carbonylamino]-3,3-dimethyl-6-oxo-2-thia-5-azabicyclo[3.2.0]heptane-4-carboxylic acid
 Molecular weight is 435.882 g/mol
 Cloxacillinum available : 250mg tablets, 500mg tablets

Generic name: Cloxacillin

Brand name(s): Clossacillina, Cloxacilina, Cloxacilline, Cloxapen, Dycill, Dynapen, Pathocil, Syntarpen, Tegopen

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