Clozaril review

Clozaril has proven to be useful in the treatment of schizophrenia. It tends to cause serious side effects if used improperly. Be sure to know the third-line treatment regimen to improve mood the right and safe way.


Clozaril is the generic name of the antipsychotic medication that blocks a number of receptors for neurotransmitters. It is primarily used to treat schizophrenia symptoms in affected roles who have not shown adequate results from other medications. Clozaril belongs to a medication class called atypical antipsychotics, which alters the activity of substances and chemicals in the brain. The medication may appear under brand names like Gen-Clozapin, Fazaclo and Leponex.

The medication comes in tablet form and should be taken orally. It has a number of side effects that are considered lethal, which explains why it was categorized under third line treatment. Clozaril has been shown to be more helpful in treating schizophrenia symptoms compared to older antipsychotic medications. Other uses for this medication include treating suicidal affected roles, paranoid individuals, manic affected roles, insomniacs and those suffering from schizoid personality, and dementia of the Lewy-body-type.


Drowsiness is the most common side effect. Patients may experience increased heart rate, headache, weight gain, sleepiness, tremor, increased salivation, abnormally low blood pressure, pyrexia, blurred vision, toilsomey urinating, constipation and paralytic ileus. Some side effects may disappear after being on the medication for 2 to 3 days. Rarely, the medication may cause extrapyramidal effects or sudden involuntary movements of the extremities, eyes and head. One serious side effect is agranulocytosis wherein white blood cell count drastically drops making the affected role vulnerable to infection and other illnesss. Other rare side effects include seizures, myocarditis, jaundice, cardiomyopathy, pulmonary embolism, respiratory depression and chest pain. These should be reported to your physician right away.


Pregnant women and breastfeeding mothers should consult their doctor before taking Clozaril. The medication may interact with various other medications including risperidone, cimetidine, epinephrine, quinidine, anti-seizure medications, phenytoin, sedatives, SSRIs or selective serotonin reuptake inhibitors and tranquilizers. Doctors should be fully informed about any herbal medicine or nutritional supplement that the individual is taking to avoid adverse reactions. Patients with known allergic reactions to the medication are contraindicated. Individuals with a history of liver illness, kidney problem, lung problem, abnormally low blood pressure, leukemia, hypertension, glaucoma, diabetes and mental illness should take the medication cautiously.

Clozaril acts by binding to serotonergic and dopamine receptors particularly dopamine at D1, D2, D3 and D5 receptors. It is also a 5-HT1A receptor partial agonist, which in turn improves mood. Furthermore, it acts as an antagonist at various adrenergic, histaminergic and cholinergic receptors. Once Clozaril is metabolized in the liver, it then binds to brain receptors improving dopamine and serotonin levels, which are responsible for mood. As a result affected roles will exhibit improvement from schizophrenic symptoms.


24 schizophrenic affected roles were given Clozaril for a span of 16 weeks. The initial dosage was 25 mg a day during the first week and amounts were increased every two weeks until affected roles took around 400 mg during the last 2 weeks. During the first 4 weeks, 14 affected roles showed significant improvement in symptoms. Another 6 affected roles improved during the next 4 weeks until 21 out of 24 were shown to be stable at the end of the study. These affected roles were provided with Clozaril only after 2 other medications were rendered ineffective.


Clozaril is a prescription medication and should only be purchased at legitimate pharmacies and clinics. There are sources that sell over the internet as well but consumers should make sure that these are authentic and certified. Consumers may ask for certification when buying online.

Avoid alcohol and tobacco products while taking Clozaril since these may decrease the effectiveness or exacerbate somnolence. Long-term use should also be monitored since tardive dyskinesia and agranulocytosis may result. Patients should expect results within the first 4 to 6 weeks but continuous improvements are possible over 6 months to 1 year.

Clozaril has the following structural formula:

Chemical structure of clozaril

 Molecular formula of clozaril is C18H19ClN4
 Clozaril available : 25mg tablets, 100mg tablets

Generic name: Clozapine

Brand name(s): Asaleptin, Clozapin, Iprox, Leponex, Lepotex

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