Cromoglicate review

Cromoglicate is a mast cell stabilizer which prevents the release of inflammation-inducing chemicals like histamine. It is used to control various conditions like asthma, allergic conjunctivitis, among others.

Cromoglicate is often marketed as sodium cromoglicate and cromolyn sodium. It is available as a nasal spray under brand names such as Nasalcrom and Rynacrom which people suffering from allergic rhinitis can use. Those who have asthma can also buy it under the brand name Intal, while those who have allergic conjunctivitis can purchase it under the brand name Crolom, Opticrom, or Optrex. Likewise, those who have ulcerative colitis and mastocytosis can purchase it under the brand name Gastrocrom.

Cromoglicate has also been proven effective in reducing symptoms of various food allergies, and in some cases, chronic migraines.

Different dosages of Cromoglicate are prescribed according to the condition being treated. For food allergy, Cromoglicate is given to adults as 200 mg table taken four times a day. The dosage is usually 100 mg for children. The dosage may be increased if the drug is not effective after 2 weeks.

For those with mastocytis, Cromoglicate is taken 4 times a day of 20 milligram dosage. For those with allergic conjunctivitis, Cromoglicate is usually administered by instilling 2 drops of a 4% solution spray, taken four times a day.

Asthmatics may use Cromoglicate as a dry powder administered four times a day of a 20 milligram dosage. For the aerosol form, the dosage is 10 milligrams taken four times a day. In case the condition does not improve, the intake can be increased up to 8 times a day. This can be lowered to 5 milligrams taken 4 times a day once the condition has improved.

Users of Cromoglicate may experience side effect ranging from skin rashes, nausea, dizziness, headache, pain and swelling in the joints, and unpleasant taste in the mouth. Users may also aggravate their asthma attacks, or suffer from pulmonary infiltrates. Others may also experience wheezing, nasal congestion, cough, and throat irritation especially after inhaling the dry powder. For those who use eye drops, there is a risk of stinging and burning feel in the eyes.

Users may also develop allergic reaction to Cromoglicate. They are advised to immediately inform a physician in case they experience symptoms of allergic reaction such as itching, rashes, swelling, difficulty in breathing and severe dizziness.

Cromoglicate may interfere when taken with other medications. Users should tell their doctors or physicians if they are taking any drugs, whether prescription or non-prescription. They are also advised not to change the dosage of Cromoglicate without the approval of their doctor or pharmacist.

Those who are using Cromoglicate for self-treatment should first clear with their physicians if they are experiencing any of these symptoms: fever, sinus pain, discolored fluid discharged from the nose, and wheezing.

Cromoglicate can also affect pregnant women, although the chances are low. Users should discuss the risks and the benefits of Cromoglicate before taking the medication.

Cromoglicate has the following structural formula:

Chemical structure of cromoglicate

• Molecular formula of cromoglicate is C23H16O11
• Chemical IUPAC Name is 5-[3-(2-carboxy-4-oxochromen-6-yl)oxy-2- hydroxypropoxy]-4-oxochromene-2-carboxylicacid
• Molecular weight is 468.3665 g/mol
Cromoglicate available : 100mg tablets

Brand name(s): Aarane, Alercom, Alerion, Allergocrom, Apo-Cromolyn, Colimune, Crolom, Cromoglycate, Cromolyn, Cromoptic, Cromovet, Fivent, Gastrocrom, Gastrofrenal, Gen-Cromoglycate, Inostral, Intal, Introl, Irtan, Lomudal, Lomupren, Lomusol, Lomuspray, Nalcrom, Nalcron, Nasalcrom, Nasmil, Opticrom, Opticron, Rynacrom, Sofro, Vistacrom, Vividrin

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