Cyclophosphamid review

Cyclophosphamid is a medication used to treat various types of cancer. Aside from being a cytotoxic medication, Cyclophosphamid is an immunosuppressive (it suppresses the immune system).

Cyclophosphamid is marketed under the brand name Cytoxan and is usable in pill form or a powder used for intravenous injection. It is prescribed to patients who are suffering from certain types of cancer such as ovarian, breast, and leukemia. It is also known to cure nephritic syndrome, an ailment of the kidneys among children.


The initial dosage of Cyclophosphamid is at least 40 mg injected in a stretch of 3 to 5 days divided in various dosages. The standard dosage for oral use is 1 to 5 mg/kg per day. The dosage is then adjusted based on the tumor's response to the medication and its side effects.

Cyclophosphamid should be taken as prescribed by your doc. While taking Cyclophosphamid, patients should drink more water and urinate more frequently. This will help the kidneys to remove the medication from the system and lower the chances of side effects.

Patients should not stop using Cyclophosphamid until the prescribed schedule is complete, even if the patient experiences nausea or vomiting.

This medication usually has to be taken for a month or two before producing positive results. The effects also depend heavily on the illness being treated.


The most common side effect is nausea. Doctors usually prescribe another medication to reduce this symptom.

Patients may also experience bleeding and inflammation of the bladder wall, or haemorrhagic cystitis characterized by blood in the urine. To reduce the chances of this, patients are advised to drink more water, preferably up to 10 glasses a day.

This medication can also affect the blood count of the patient, result in hair loss, irregular menstrual periods, and mouth ulcers. In case a patient develops these symptoms after taking Cyclophosphamid, he or she should immediately inform their doc.

Patients who come into close contact with a person with chicken pox are advised to stop taking Cyclophosphamid and immediately consult their doc. This usually requires a special antiviral treatment since chicken pox can be severe to patients who are undergoing treatment with Cyclophosphamid.

Since Cyclophosphamid may affect the bladder and the blood, docs may arrange for a blood and urine examination before allowing the patient to start treatment with Cyclophosphamid. Regular examinations are required while the patient takes Cyclophosphamid. Patients should not take Cyclophosphamid unless they are undergoing regular blood and urine examinations.


Certain medications interact negatively with other medications. Patients should make it a point to inform their physicians if they are beginning to take new medications while taking Cyclophosphamid.

Taking Cyclophosphamid may lead to a decrease in fertility among women and men; so young users are advised to use this medication with caution.


Pregnant women should never take this medication. Cyclophosphamid may also be passed on to infants so breastfeeding mothers should not take this medication.

Cyclophosphamid has the following structural formula:

Chemical structure of cyclophosphamid

 Molecular formula of cyclophosphamid is C7H15C12N2O2P·H2O
 Chemical IUPAC Name is 2-[bis(2-chloroethyl)amino] tetrahydro-2H-13,2-oxazaphosphorine 2-oxide monohydrate
 Molecular weight is 279.1 g/mol
 Cyclophosphamid available : 25mg tablets, 50mg tablets

Generic name: Cyclophosphamide

Brand name(s): Clafen, Claphene, Cyclophosphamidum, Cyclophosphan, Cyclophosphane, Cyclophosphoramide, Cyclostin, Cyklofosfamid, Cytophosphan, Cytoxan, Endoxan, Endoxan R, Endoxana, Endoxanal, Endoxane, Enduxan, Genoxal, Hexadrin, Lyophilized Cytoxan, Mitoxan, Neosar, Procytox, Semdoxan, Sendoxan, Senduxan, Zyklophosphamid

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