Cyclophosphamidum review

Cyclophosphamidum is used to treat various types of cancer. Aside from being a cytotoxic medication, Cyclophosphamidum is an immunosuppressive (it suppresses the immune system).

Cyclophosphamidum is marketed under the brand name Cytoxan and is available in tablet form or a powder used for intravenous injection. It is prescribed to patients suffering from certain types of cancer such as ovarian, breast, and leukemia. It is also known to cure nephritic syndrome, an ailment of the kidneys among children.


The initial dose of Cyclophosphamidum is at least 40 mg injected in a stretch of 3 to 5 days divided into several doses. The standard dosage for oral use is 1 to 5 mg/kg per day. The dose is then adjusted based on the tumor’s response to the medication and side effects.

Cyclophosphamidum should be taken as prescribed by your doctor. While taking Cyclophosphamidum, patients should drink more water and urinate more frequently. This will help the kidneys remove the medication from the system and lower the possibility of side effects.

Patients should not stop using Cyclophosphamidum until the prescribed schedule is complete, even if the patient experiences nausea or vomiting.

This medication usually needs to be taken for a month or two before producing positive results. The effects also depend heavily on the illness being treated.


The most common side effect is nausea. Doctors usually prescribe another medication to reduce this symptom.

Patients may also experience bleeding and inflammation of the bladder wall, or haemorrhagic cystitis characterized by blood in the urine. To reduce the chances of this, patients are advised to drink more water, preferably up to 10 glasses a day.

This medication can also affect the blood count of the patient, result in hair loss, irregular menstrual periods, and mouth ulcers. In case a patient develops these symptoms after taking Cyclophosphamidum, he or she should immediately inform their doctor.

Patients who come into close contact with a person with chicken pox are advised to stop taking Cyclophosphamidum and immediately consult their doctor. This usually requires a special antiviral treatment since chicken pox can be severe to patients who are undergoing treatment with Cyclophosphamidum.

Since Cyclophosphamidum may affect the bladder and the blood, doctors may arrange for a blood and urine examination before allowing the patient to start treatment with Cyclophosphamidum. Regular examinations are required while the patient takes Cyclophosphamidum. Patients should not take Cyclophosphamidum unless they are undergoing regular blood and urine examinations.


Certain medications interact negatively with other medications. Patients should inform their physicians if they are beginning to take new medications while taking Cyclophosphamidum.

Taking Cyclophosphamidum may lead to a decrease in fertility. Patients are advised to use this medication with caution.


Pregnant women should not take this medication. Cyclophosphamidum may be passed on to infants so breastfeeding mothers should not take this medication.

Cyclophosphamidum has the following structural formula:

Chemical structure of cyclophosphamidum

 Molecular formula of cyclophosphamidum is C7H15C12N2O2P·H2O
 Chemical IUPAC Name is 2-[bis(2-chloroethyl)amino] tetrahydro-2H-13,2-oxazaphosphorine 2-oxide monohydrate
 Molecular weight is 279.1 g/mol
 Cyclophosphamidum available : 25mg tablets, 50mg tablets

Generic name: Cyclophosphamide

Brand name(s): Clafen, Claphene, Cyclophosphamid, Cyclophosphan, Cyclophosphane, Cyclophosphoramide, Cyclostin, Cyklofosfamid, Cytophosphan, Cytoxan, Endoxan, Endoxan R, Endoxana, Endoxanal, Endoxane, Enduxan, Genoxal, Hexadrin, Lyophilized Cytoxan, Mitoxan, Neosar, Procytox, Semdoxan, Sendoxan, Senduxan, Zyklophosphamid

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