Cyclophosphane review

Cyclophosphane is used to treat various types of cancer. Aside from being a cytotoxic medication, it is an immunosuppressive (it suppresses the immune system).

Cyclophosphane is available under the brand name Cytoxan and is available in tablet form or a powder used for intravenous injection. It is prescribed to patients with certain types of cancer such as ovarian, breast, and leukemia and is also known to cure nephritic syndrome, an ailment of the kidneys among children.


The initial dose of Cyclophosphane is a minimum 40 mg injected in a stretch of 3 to 5 days divided into several doses. The standard dose for oral use is 1 to 5 mg/kg per day. It is then adjusted based on the tumor’s response to the medication and the side effects.


Cyclophosphane is to be taken as prescribed by your doctor. While taking Cyclophosphane, patients should drink more water, which will cause them to urinate more frequently. This will help the kidneys remove the medication from their system and lower the possibility of side effects.

Patients should not stop taking Cyclophosphane until the prescribed period is complete, even if the patient experiences nausea or vomiting.

This medication usually needs to be taken for a month or two before seeing positive results. The results also depend heavily on the illness being treated.


The most common side effect is nausea. Due to this, doctors usually prescribe another medication to reduce this symptom.

Patients may experience bleeding and inflammation of the bladder wall, or haemorrhagic cystitis characterized by blood in the urine. To reduce the chances of this, patients are advised to drink more water, preferably about 10 glasses a day.

This medication can affect the blood count of the patient, result in hair loss, irregular menstrual periods, and mouth ulcers. In case a patient develops any of these symptoms after taking Cyclophosphane, he or she should immediately inform their doctor.

Patients who come into contact with a person with chicken pox are advised to stop taking Cyclophosphane and immediately consult their doctor. This usually requires a special antiviral treatment since chicken pox can be severe to patients undergoing treatment with Cyclophosphane.

Since Cyclophosphane may affect the bladder and the blood, your doctor may arrange for a blood and urine examination before allowing you to start treatment with Cyclophosphane. Regular examinations are required while the patient takes Cyclophosphane. Patients should not take Cyclophosphane unless they are undergoing regular blood and urine examinations.


Certain medications interact negatively with other medications. Patients should inform their physicians if they are beginning to take new medications while taking Cyclophosphane.

Taking Cyclophosphane may lead to a decrease in fertility. Patients are advised to use this medication with caution.


Pregnant women should not take this medication. Cyclophosphane may be passed on to infants so breastfeeding mothers should not take this medication.

Cyclophosphane has the following structural formula:

Chemical structure of cyclophosphane

 Molecular formula of cyclophosphane is C7H15C12N2O2P·H2O
 Chemical IUPAC Name is 2-[bis(2-chloroethyl)amino] tetrahydro-2H-13,2-oxazaphosphorine 2-oxide monohydrate
 Molecular weight is 279.1 g/mol
 Cyclophosphane available : 25mg tablets, 50mg tablets

Generic name: Cyclophosphamide

Brand name(s): Clafen, Claphene, Cyclophosphamid, Cyclophosphamidum, Cyclophosphan, Cyclophosphoramide, Cyclostin, Cyklofosfamid, Cytophosphan, Cytoxan, Endoxan, Endoxan R, Endoxana, Endoxanal, Endoxane, Enduxan, Genoxal, Hexadrin, Lyophilized Cytoxan, Mitoxan, Neosar, Procytox, Semdoxan, Sendoxan, Senduxan, Zyklophosphamid

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