Cyclophosphoramide review

Cyclophosphoramide is used to treat various types of cancer. Aside from being a cytotoxic medication, it is an immunosuppressive (it suppresses the immune system).

Cyclophosphoramide is useable under the brand name Cytoxan and is useable in tablet form or a powder used for intravenous injection. It is prescribed to patients with certain types of cancer such as ovarian, breast, and leukemia and is also known to cure nephritic syndrome, an ailment of the kidneys among children.


The initial dose of Cyclophosphoramide is a minimum 40 mg injected in a stretch of 3 to 5 days divided into several doses. The standard dose for oral use is 1 to 5 mg/kg per day. It is then adjusted based on the tumor's response to the medication and the side effects.


Cyclophosphoramide is to be taken as prescribed by your physician. While taking Cyclophosphoramide, patients should drink more water, which will cause them to urinate more frequently. This will help the kidneys remove the medication from their system and lower the possibility of side effects.

Patients should not stop taking Cyclophosphoramide until the prescribed period is complete, even if the patient experiences nausea or vomiting.

This medication usually needs to be taken for a month or two before seeing positive results. The results also depend heavily on the illness being treated.


The most common side effect is nausea. Due to this, physicians usually prescribe another medication to reduce this symptom.

Patients may experience bleeding and inflammation of the bladder wall, or haemorrhagic cystitis characterized by blood in the urine. To reduce the chances of this, patients are advised to drink more water, preferably about 10 glasses a day.

This medication can affect the blood count of the patient, result in baldness, irregular menstrual periods, and mouth ulcers. In case a patient develops any of these symptoms after taking Cyclophosphoramide, he or she should immediately inform their physician.

Patients who come into contact with a person with chicken pox are advised to stop taking Cyclophosphoramide and immediately consult their physician. This usually requires a special antiviral treatment since chicken pox can be severe to patients undergoing treatment with Cyclophosphoramide.

Since Cyclophosphoramide may affect the bladder and the blood, your physician may arrange for a blood and urine examination before allowing you to start taking Cyclophosphoramide. Regular examinations are required while taking Cyclophosphoramide. Patients should not take this medication unless they are undergoing regular blood and urine examinations.


Certain medicaments interact negatively with this medication. Patients should inform their physicians if they start any new medicaments while taking Cyclophosphoramide.

Taking Cyclophosphoramide may lead to a decrease in fertility. Patients are advised to use this medication with caution.


Pregnant women should not take this medication. Cyclophosphoramide may be passed on to infants so breastfeeding mothers should not take this medication.

Cyclophosphoramide has the following structural formula:

Chemical structure of cyclophosphoramide

 Molecular formula of cyclophosphoramide is C7H15C12N2O2P·H2O
 Chemical IUPAC Name is 2-[bis(2-chloroethyl)amino] tetrahydro-2H-13,2-oxazaphosphorine 2-oxide monohydrate
 Molecular weight is 279.1 g/mol
 Cyclophosphoramide available : 25mg tablets, 50mg tablets

Generic name: Cyclophosphamide

Brand name(s): Clafen, Claphene, Cyclophosphamid, Cyclophosphamidum, Cyclophosphan, Cyclophosphane, Cyclostin, Cyklofosfamid, Cytophosphan, Cytoxan, Endoxan, Endoxan R, Endoxana, Endoxanal, Endoxane, Enduxan, Genoxal, Hexadrin, Lyophilized Cytoxan, Mitoxan, Neosar, Procytox, Semdoxan, Sendoxan, Senduxan, Zyklophosphamid

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