Cyclosporine review

Cyclosporine is an immunosuppressive drug. Its most popular use is in combating organ rejection for patients who just had an organ transplant – skin, pancreas, small intestine, kidney, lung, heart, and bone marrow. By suppressing the activity of the immune system, Cyclosporine helps the replaced organ work well with the body’s system.

Discovered in early 1970s, Cyclosporine made transplantation possible without increased risk of morbidity. At first, the drug was intended for antimicrobial use. When its immunosuppressive properties were recognized, immunological tests and investigations were soon initiated. The first successful use of Cyclosporine to an organ transplant patient occurred on March 9, 1980. Three years after, in 1983, Cyclosporine was approved for clinical use.

Aside from its role in transplantation, Cyclosporine is also effective as a treatment for Psoriasis, Rheumatoid Arthritis, and Atopic Dermatitis. It has also been found useful in protecting injury patients from brain damage. Cyclosporine as a treatment for Psoriasis is found to be the safest and quickest with very mild side effects, especially when used for a short period of time.

Cyclosporine comes in capsule and liquid suspension to be taken orally by mouth twice a day. The dosage requirement is different for every patient. Some of the factors that interfere in the prescription include the patient’s condition, blood pressure, weight, and how well his kidneys are working. At any point within the medication period, the doctor may adjust the dose depending on the patient’s response to the drug. Normally, patients who are being treated with Cyclosporine are required to take blood tests every so often. This is to monitor the levels of the medicine obtained in the blood. It is advisable that you take Cyclosporine after the blood test. If you missed a dose, take it as soon as you realize it. However, if the missed dose is too close to the next schedule, it is better that you discard that dose and proceed with your normal dosing schedule.

As mentioned above, Cyclosporine is found to be very effective with mild side effects. Some of the mild side effects that are usually experienced by patients who are taking it for a short period include head ache, nausea, joint pain, and gum swelling. Cyclosporine intake can also elevate the patient’s cholesterol and triglycerides level as well as blood pressure. It is important that you are closely monitored by your doctor while under Cyclosporine medication.

There are a couple of precautions you need to take while under Cyclosporine treatment to be on the safe side. Do not take any new medicines without the knowledge of your doctor. Drug interactions may cause damage to your health; it can even be fatal. So it is important that you take extra care. Also, you must not take grapefruit or grapefruit juice while taking Cyclosporine. Grapefruit interferes in the levels of Cyclosporine obtained in your blood.

Always wait for your doctor’s instructions. Do not stop or continue taking the medicine without your doctor’s advice. Also, take note of the physical discomfort that taking the medicine brings. Persistence of side effects, especially if it is greater than the benefits that you get from the drug, must be taken to your doctor’s attention.

Cyclosporine has the following structural formula:

Chemical structure of cyclosporine

• Molecular formula of cyclosporine is C62H111N11O12
• Chemical IUPAC Name is 30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methyl-hex-4-enyl]-1,4,7,10,12,15,19,25,28- nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-dipropan-2-yl-1,4,7,10,13,16, 19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
• Molecular weight is 1202.61 g/mol
Cyclosporine available : 25mg capsules, 100mg capsules

Brand name(s): Gengraf, Neoral, Restasis, Sandimmune

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